New eudesmanolides from Artemisia verlotorum and their potential targets of hepatocellular carcinoma by network pharmacology
文献类型：期刊论文
| 作者 | Dong,Wei; Yang,Ke-Xin; He,Xiao-Feng; Li,Tian-Ze; Chen,Ji-Jun
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2023 |
| 卷号 | 167页码:105491 |
| 关键词 | Artemisia verlotorum Eudesmanolides Network pharmacology Molecular docking Surface Plasmon Resonance AURORA KINASE SESQUITERPENOIDS AURKA EXPRESSION |
| ISSN号 | 1873-6971 |
| DOI | 10.1016/j.fitote.2023.105491 |
| 英文摘要 | Fractionation of the ethanol extract of Artemisia verlotorum led to the identification of eight undescribed eudesmane-type sesquiterpenoids, artemverlolides A-H (1-8). Their structures were determined by spectral analyses (HRESIMS, 1D and 2D NMR, IR, and ECD). Network pharmacology predicted that compounds 1-8 might be target on AURKA, CCNA2, CYP2C19, and EPHX2 with possibly antihepatoma effect from Swiss TargetPrediction and Gene Expression Omnibus database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses showed that the targets significantly enriched in FoxO signaling pathway. The molecular docking suggested that compound 8 had high binding affinity with AURKA. Furthermore, the interaction between compound 8 and AURKA was determined by Surface Plasmon Resonance (SPR) assay. The result suggested that compound 8 bound to AURKA with KD value of 68.0 mu M and was consistent with the predicted data, demonstrating that AURKA might be one of acting targets of 8. |
| 学科主题 | Pharmacology & Pharmacy |
| WOS记录号 | WOS:000969960900001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75513]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Dong,Wei,Yang,Ke-Xin,He,Xiao-Feng,et al. New eudesmanolides from Artemisia verlotorum and their potential targets of hepatocellular carcinoma by network pharmacology[J]. FITOTERAPIA,2023,167:105491. |
| APA | Dong,Wei,Yang,Ke-Xin,He,Xiao-Feng,Li,Tian-Ze,&Chen,Ji-Jun.(2023).New eudesmanolides from Artemisia verlotorum and their potential targets of hepatocellular carcinoma by network pharmacology.FITOTERAPIA,167,105491. |
| MLA | Dong,Wei,et al."New eudesmanolides from Artemisia verlotorum and their potential targets of hepatocellular carcinoma by network pharmacology".FITOTERAPIA 167(2023):105491. |
入库方式： OAI收割
来源：昆明植物研究所
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