Artemleucolides A-L, eudesmane-type sesquiterpenoids from Artemisia leucophylla and their antihepatoma cytotoxicity
文献类型：期刊论文
| 作者 | Wang,Yuan; Ma,Yun-Bao; Huang,Xiao-Yan; Li,Tian-Ze; He,Xiao-Feng; Zhang,Xue-Mei; Chen,Ji-Jun
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2023 |
| 卷号 | 165页码:105399 |
| 关键词 | Artemisia leucophylla Artemleucolides A-L Eudesmane-type sesquiterpenoids Cytotoxicity ASSIGNMENT LACTONES |
| ISSN号 | 1873-6971 |
| DOI | 10.1016/j.fitote.2022.105399 |
| 英文摘要 | Twelve undescribed and 13 known eudesmane-type sesquiterpenoids were obtained from Artemisia leucophylla, and structurally elucidated based on comprehensive analyses of spectral data, including HRESIMS, IR, 1D and 2D NMR, and ECD calculation. The absolute configuration of compound 1 was determined by a single X-ray single crystal diffraction. Chemically, compounds 1-5 featured unprecedented 1,2-seco-1-nor-eudesmane-type skeleton with a cis-fused 6/5 bicyclic system. Antihepatoma evaluation against three human hepatoma cell lines (HepG2, Huh7, and SK-Hep-1) for all compounds demonstrated that compound 7 displayed the most active cytotoxicity with IC50 values of 35.1, 35.0, and 32.7 mu\M. |
| 学科主题 | Pharmacology & Pharmacy |
| WOS记录号 | WOS:000920065500001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75520]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Wang,Yuan,Ma,Yun-Bao,Huang,Xiao-Yan,et al. Artemleucolides A-L, eudesmane-type sesquiterpenoids from Artemisia leucophylla and their antihepatoma cytotoxicity[J]. FITOTERAPIA,2023,165:105399. |
| APA | Wang,Yuan.,Ma,Yun-Bao.,Huang,Xiao-Yan.,Li,Tian-Ze.,He,Xiao-Feng.,...&Chen,Ji-Jun.(2023).Artemleucolides A-L, eudesmane-type sesquiterpenoids from Artemisia leucophylla and their antihepatoma cytotoxicity.FITOTERAPIA,165,105399. |
| MLA | Wang,Yuan,et al."Artemleucolides A-L, eudesmane-type sesquiterpenoids from Artemisia leucophylla and their antihepatoma cytotoxicity".FITOTERAPIA 165(2023):105399. |
入库方式： OAI收割
来源：昆明植物研究所
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