Dimeric benzylisoquinoline alkaloids from Thalictrum delavayi and their biological activities
文献类型：期刊论文
| 作者 | Jin,Qiong; Qin,Xu-Jie; Dai,Zhi; Zhao,Yun; Zhu,Yan-Yan; Chen,Shan-Shan; Liu,Ya-Ping; Luo,Xiao-Dong
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2023 |
| 卷号 | 164页码:105356 |
| 关键词 | Thalictrum delavayi Ranunculaceae Bisbenzylisoquinoline alkaloids Cytotoxicities Immunosuppressive effects CYCLOARTANE GLYCOSIDES APORPHINE LEAVES PLANTS |
| ISSN号 | 1873-6971 |
| DOI | 10.1016/j.fitote.2022.105356 |
| 英文摘要 | A phytochemical investigation of the whole plants of T. delavayi led to the isolation of five new dimeric ben-zylisoquinoline alkaloids, thalidelavines A-E (1-5), together with six known congeners (6-11). The structures and absolute configurations of new compounds were established based on analyses of spectroscopic data, ECD calculations, and single crystal X-ray crystallography. Thalidelavines A-E (1-5) were structurally complex bis-benzylisoquinoline alkaloids with various configurations. These isolated alkaloids were evaluated for their cytotoxic and immunosuppressive effects. Among them, both 9 and 10 displayed significant cytotoxicities against T98G cell lines with an IC50 value of 2.1 mu M, compared with the positive CPT-11 (IC50 = 3.0 mu M). In addition, 5-7 showed remarkable immunosuppressive effects. These findings not only enrich the structural diversity of bisbenzylisoquinoline alkaloids, but also provide potential candidates for the further development of the anti-tumor and immunosuppressive agents. |
| 学科主题 | Pharmacology & Pharmacy |
| WOS记录号 | WOS:000895484400008 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75522]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Jin,Qiong,Qin,Xu-Jie,Dai,Zhi,et al. Dimeric benzylisoquinoline alkaloids from Thalictrum delavayi and their biological activities[J]. FITOTERAPIA,2023,164:105356. |
| APA | Jin,Qiong.,Qin,Xu-Jie.,Dai,Zhi.,Zhao,Yun.,Zhu,Yan-Yan.,...&Luo,Xiao-Dong.(2023).Dimeric benzylisoquinoline alkaloids from Thalictrum delavayi and their biological activities.FITOTERAPIA,164,105356. |
| MLA | Jin,Qiong,et al."Dimeric benzylisoquinoline alkaloids from Thalictrum delavayi and their biological activities".FITOTERAPIA 164(2023):105356. |
入库方式： OAI收割
来源：昆明植物研究所
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