Heterodimers with a cucurbitane-type triterpenoid skeleton from the branches of Elaeocarpus dubius
文献类型：期刊论文
| 作者 | Hu,Dong-Bao; Wei,Shu-Ya; Yang,Jun; Zhang,Dong-Dong; Duan,Xiao-Yan; Yan,Hui; Yang,Xing-Zhi; Bai,Xue; Luo,Ji-Feng; Yang,Jing-Hua |
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2023 |
| 卷号 | 207页码:113581 |
| 关键词 | Elaeocarpus dubius Elaeocarpaceae Cucurbitacins Antioxidant Neuroprotective CONSTITUENTS ELUCIDATION GLYCOSIDES |
| ISSN号 | 1873-3700 |
| DOI | 10.1016/j.phytochem.2022.113581 |
| 英文摘要 | Four undescribed and two known cucurbitane-type triterpenoids, including two heterodimers, elaeocarpudubins A and B, were isolated from the branches of Elaeocarpus dubius (Elaeocarpaceae). The chemical structures of these undescribed isolates were determined by analyses of 1D and 2D NMR and MS data, electronic circular dichroism (ECD) calculations, and chemical transformation. Biogenetically, elaeocarpudubins A and B might be derived from cucurbitacin F through Michael addition with vitamin C and (-)-catechin, respectively. These six isolates were evaluated for their cytotoxic activities against human leukemia HL-60, human lung adenocarcinoma A549, human hepatoma SMMC-7721, human breast cancer MCF-7, human colon cancer SW480, and paclitaxel-resistant A549 (A549/Taxol) cell lines, for their antioxidant properties using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, and for their differentiation effects on nerve growth factor (NGF)-mediated neurite outgrowth in rat pheochromocytoma PC12 cells. Cucurbitacins F (IC50 of 4.98-38.11 mu M) and D (IC50 of 0.03-4.40 mu M) showed growth-inhibitory activities against these six cancer cell lines. Elaeocarpudubin B (IC50 of 61.04 mu M) and elaeocarpudoside B (IC50 of 6.93 mu M) showed antioxidant activities. Elaeocarpudubin B and elaeocarpudoside B also showed neurite outgrowth-promoting activities in PC12 cells at a concentration of 10 mu M. |
| 学科主题 | Biochemistry & Molecular Biology ; Plant Sciences |
| WOS记录号 | WOS:000917925000001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75531]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Hu,Dong-Bao,Wei,Shu-Ya,Yang,Jun,et al. Heterodimers with a cucurbitane-type triterpenoid skeleton from the branches of Elaeocarpus dubius[J]. PHYTOCHEMISTRY,2023,207:113581. |
| APA | Hu,Dong-Bao.,Wei,Shu-Ya.,Yang,Jun.,Zhang,Dong-Dong.,Duan,Xiao-Yan.,...&Wang,Yue-Hu.(2023).Heterodimers with a cucurbitane-type triterpenoid skeleton from the branches of Elaeocarpus dubius.PHYTOCHEMISTRY,207,113581. |
| MLA | Hu,Dong-Bao,et al."Heterodimers with a cucurbitane-type triterpenoid skeleton from the branches of Elaeocarpus dubius".PHYTOCHEMISTRY 207(2023):113581. |
入库方式： OAI收割
来源：昆明植物研究所
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