Atractylodinol prevents pulmonary fibrosis through inhibiting TGF-β receptor 1 recycling by stabilizing vimentin
文献类型：期刊论文
| 作者 | Hao,Mengjiao; Guan,Zhuoji; Zhang,Zhikang; Ai,Haopeng; Peng,Xing; Zhou,Huihao; Xu,Jun ; Gu,Qiong
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| 刊名 | MOLECULAR THERAPY
 |
| 出版日期 | 2023 |
| 卷号 | 31期号:10页码:3015-3033 |
| 关键词 | INTERMEDIATE-FILAMENT PROTEIN MECHANISMS PATHWAYS ADHESION IDENTIFICATION SMAD |
| ISSN号 | 1525-0024 |
| DOI | 10.1016/j.ymthe.2023.08.017 |
| 英文摘要 | Pirfenidone and nintedanib are only anti-pulmonary fibrosis (PF) drugs approved by the FDA. However, they are not target specific, and unable to modify the disease status. Therefore, it is still desirable to discover more effective agents against PF. Vimentin (VIM) plays key roles in tissue regeneration and wound healing, but its molecular mechanism remains unknown. In this work, we demonstrated that atractylodinol (ATD) significantly inhibits TGF-beta 1-induced epithelial-mesenchymal transition and fibroblast-to-myofibroblast transition in vitro. ATD also reduces bleomycin-induced lung injury and fibrosis in mice models. Mechanistically, ATD inhibited TGF-beta receptor I recycling by binding to VIM (K-D = 454 nM) and inducing the formation of filamentous aggregates. In conclusion, we proved that ATD (derived from Atractylodes lancea) modified PF by targeting VIM and inhibiting the TGF-beta/Smad signaling pathway. Therefore, VIM is a druggable target and ATD is a proper drug candidate against PF. We prove a novel VIM function that TGF-beta-receptor I recycling. These findings paved the way to develop new targeted therapeutics against PF. |
| WOS记录号 | WOS:001088359100001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75535]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Hao,Mengjiao,Guan,Zhuoji,Zhang,Zhikang,et al. Atractylodinol prevents pulmonary fibrosis through inhibiting TGF-β receptor 1 recycling by stabilizing vimentin[J]. MOLECULAR THERAPY,2023,31(10):3015-3033. |
| APA | Hao,Mengjiao.,Guan,Zhuoji.,Zhang,Zhikang.,Ai,Haopeng.,Peng,Xing.,...&Gu,Qiong.(2023).Atractylodinol prevents pulmonary fibrosis through inhibiting TGF-β receptor 1 recycling by stabilizing vimentin.MOLECULAR THERAPY,31(10),3015-3033. |
| MLA | Hao,Mengjiao,et al."Atractylodinol prevents pulmonary fibrosis through inhibiting TGF-β receptor 1 recycling by stabilizing vimentin".MOLECULAR THERAPY 31.10(2023):3015-3033. |
入库方式： OAI收割
来源：昆明植物研究所
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