Identification of undescribed key impurities of homoharringtonine bulk drug
文献类型：期刊论文
| 作者 | Yu,Yang; Wu,Jing; Yue,Cong-Yong; Zhang,Tao; Cai,Xiang-Hai
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| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2023 |
| 关键词 | Cephalotaxus fortunei neohomoharringtonines A-C homoharringtonine structure identification key impurities |
| ISSN号 | 1478-6427 |
| DOI | 10.1080/14786419.2023.2175358 |
| 英文摘要 | The knowledge of impurities is an important issue and the base of quality control in modern drugs. To date, the quality control of the antitumor drug homoharringtonine (HHT) is still not sufficiently solved and needs to be improved. Six main impurities, drupacine, cephalotaxine, desmethylcephalotaxinone, harringtonine, 3-O-acetyl-cephalotaxine and 2'R,3'S-isoharringtonine were traced during HHT drug production by HPLC and LC-MS analyses. Additionally, we were able to isolate and identify three undescribed key trace impurities, neohomoharringtonines A-C. Their structures were established by 1D-, and 2D NMR experiments combined with mass spectrometry. An improved quality inspection ability of HHT was constructed. |
| 学科主题 | Chemistry ; Pharmacology & Pharmacy |
| WOS记录号 | WOS:000934342900001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75539]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Yu,Yang,Wu,Jing,Yue,Cong-Yong,et al. Identification of undescribed key impurities of homoharringtonine bulk drug[J]. NATURAL PRODUCT RESEARCH,2023. |
| APA | Yu,Yang,Wu,Jing,Yue,Cong-Yong,Zhang,Tao,&Cai,Xiang-Hai.(2023).Identification of undescribed key impurities of homoharringtonine bulk drug.NATURAL PRODUCT RESEARCH. |
| MLA | Yu,Yang,et al."Identification of undescribed key impurities of homoharringtonine bulk drug".NATURAL PRODUCT RESEARCH (2023). |
入库方式： OAI收割
来源：昆明植物研究所
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