Three rare nor-sesquiterpenoids with lipid-lowering activity from Belamcanda chinensis
文献类型：期刊论文
| 作者 | Qianshi,Yunhua; Huang,Lei; Jin,Jun; Li,Yanmei; Li,Yanan; Hao,Xiaojiang ; Yuan,Chunmao
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| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2023 |
| 卷号 | 21期号:48页码:9640-9646 |
| ISSN号 | 1477-0539 |
| DOI | 10.1039/d3ob01724a |
| 英文摘要 | Belchinoids A-C (1-3), three unusual nor-sesquiterpenoids, along with a new isoflavone (4), were isolated from the roots of Belamcanda chinensis, a traditional Chinese medicine. To the best of our knowledge, compound 1 represents the first C13 nor-sesquiterpenoid with a five membered carbon ring. Compounds 2 and 3 are rare C14 chained nor-sesquiterpenoids. Their structures were fully characterized based on extensive spectroscopic data and quantum chemistry calculation. Three compounds (1, 2, and 4) showed potent inhibitory effects on lipid accumulation in an oleic acid-treated HepG2 cell model. In particular, compound 2 exhibited the most potent inhibitory effect on triglyceride accumulation at a low concentration of 2.5 mu M, better than the positive control atorvastatin. The plausible biosynthetic pathway of the three nor-sesquiterpenoids (1-3) is also proposed. |
| WOS记录号 | WOS:001116599200001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75542]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Qianshi,Yunhua,Huang,Lei,Jin,Jun,et al. Three rare nor-sesquiterpenoids with lipid-lowering activity from Belamcanda chinensis[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2023,21(48):9640-9646. |
| APA | Qianshi,Yunhua.,Huang,Lei.,Jin,Jun.,Li,Yanmei.,Li,Yanan.,...&Yuan,Chunmao.(2023).Three rare nor-sesquiterpenoids with lipid-lowering activity from Belamcanda chinensis.ORGANIC & BIOMOLECULAR CHEMISTRY,21(48),9640-9646. |
| MLA | Qianshi,Yunhua,et al."Three rare nor-sesquiterpenoids with lipid-lowering activity from Belamcanda chinensis".ORGANIC & BIOMOLECULAR CHEMISTRY 21.48(2023):9640-9646. |
入库方式： OAI收割
来源：昆明植物研究所
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