Artemongolides A-F, undescribed sesquiterpenoid dimers from Artemisia mongolica and their antihepatic fibrosis activities
文献类型：期刊论文
| 作者 | Shang,Chong; Huang,Xiao-Yan; Wang,Yuan; Dong,Wei; He,Xiao-Feng; Li,Tian-Ze; Chen,Ji-Jun
|
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2023 |
| 关键词 | GUAIANOLIDE LACTONES ARGYI |
| ISSN号 | 1477-0539 |
| DOI | 10.1039/d2ob02182j |
| 英文摘要 | Artemongolides A-E (1-5), an unusual class of diseco-guaianolides featuring a rare fused 7-methylbicyclo[2.2.1]-2-ene-7-heptanol ring system, and artemongolide F (6), the first example of [4 + 2] Diels-Alder type adducts presumably incorporating a chain farnesane sesquiterpene and a guaianolide diene, were isolated from the whole plant of Artemisia mongolica. Their structures were elucidated based on the spectroscopic analyses of UV, IR, MS, and 1D and 2D NMR spectra. The absolute configurations of artemongolides A (1) and F (6) were determined by single-crystal X-ray crystallography, and those of artemongolides B-E (2-5) were established by ECD calculations. Cytotoxicity evaluation suggested that compound 1 exhibited activity against HSC-LX2 cells with an IC50 value of 165.0 mu M, equivalent to that of the positive control silybin (IC50, 146.4 mu M). Preliminary mechanism studies revealed that compound 1 could inhibit the deposition of human collagen type I (Col I), human hyaluronic acid (HA), and human laminin (HL) with IC50 values of 123.8, 160.4, and 139.20 mu M. |
| 学科主题 | Chemistry |
| WOS记录号 | WOS:000908291100001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75543]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Shang,Chong,Huang,Xiao-Yan,Wang,Yuan,et al. Artemongolides A-F, undescribed sesquiterpenoid dimers from Artemisia mongolica and their antihepatic fibrosis activities[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2023. |
| APA | Shang,Chong.,Huang,Xiao-Yan.,Wang,Yuan.,Dong,Wei.,He,Xiao-Feng.,...&Chen,Ji-Jun.(2023).Artemongolides A-F, undescribed sesquiterpenoid dimers from Artemisia mongolica and their antihepatic fibrosis activities.ORGANIC & BIOMOLECULAR CHEMISTRY. |
| MLA | Shang,Chong,et al."Artemongolides A-F, undescribed sesquiterpenoid dimers from Artemisia mongolica and their antihepatic fibrosis activities".ORGANIC & BIOMOLECULAR CHEMISTRY (2023). |
入库方式： OAI收割
来源：昆明植物研究所
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