Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy
文献类型：期刊论文
| 作者 | Yan,Ying; Ran,Xiaoqian; Wang,Dan; Zhang,Xiong; Peng,Mingyou; Yan,Xiaoyan; Tang,Lei; Liang,Hong; Qin,Xujie ; Di,Ying-Tong
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| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2023 |
| 卷号 | 21期号:3页码:514-519 |
| 关键词 | UBIQUITIN-PROTEASOME SYSTEM ALZHEIMERS-DISEASE CONSTITUENTS LIMONOIDS TFEB NEURODEGENERATION |
| ISSN号 | 1477-0539 |
| DOI | 10.1039/d2ob01965e |
| 英文摘要 | Munronin V (1), isolated from Munronia henryi Harms, is the first example, to the best of our knowledge, of an unprecedented 7/7/6 tricarbocyclic framework featuring an unusual A,B-seco-limonoid ring. The structures of munronin V were established from extensive spectroscopic and electronic circular dichroism (ECD) analyses. The novel A,B-seco with two seven-membered lactones was formed as a result of Baeyer-Villiger oxidation. Compound 1 activated autophagy and inhibited Tau pathology as revealed by flow cytometric analyses, confocal imaging analysis and western blotting, and this effect was mediated by transcription factor EB (TFEB). These findings suggested that 1 might have potential as a compound for combating Alzheimer's disease. |
| 学科主题 | Chemistry |
| WOS记录号 | WOS:000906757600001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75544]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Yan,Ying,Ran,Xiaoqian,Wang,Dan,et al. Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2023,21(3):514-519. |
| APA | Yan,Ying.,Ran,Xiaoqian.,Wang,Dan.,Zhang,Xiong.,Peng,Mingyou.,...&Yao,Yong-Gang.(2023).Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy.ORGANIC & BIOMOLECULAR CHEMISTRY,21(3),514-519. |
| MLA | Yan,Ying,et al."Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy".ORGANIC & BIOMOLECULAR CHEMISTRY 21.3(2023):514-519. |
入库方式： OAI收割
来源：昆明植物研究所
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