The protective effect of Allium chinense on anti-cerebral anoxia through regulating NLRP3/NF-?B
文献类型：期刊论文
| 作者 | Xiao,Xia; Liu,Yang-Yang; Yan,Xiao-Jun; Wang,Xiao-Na; Hu,Bin-Yuan; Chen,Song; Zhu,Yan-Yan; Wang,Zhao-Jie; Xie,Tian-Zhen; He,Ying-Jie |
| 刊名 | INDUSTRIAL CROPS AND PRODUCTS
 |
| 出版日期 | 2023 |
| 卷号 | 196页码:116499 |
| 关键词 | Allium chinense Cerebral anoxia Intracellular reactive oxygen species NLRP3 NF-?B Nutritional strategy ACID MITOCHONDRIA CONTRIBUTES METALATION INHIBITORS SAPONINS DAMAGE |
| ISSN号 | 1872-633X |
| DOI | 10.1016/j.indcrop.2023.116499 |
| 英文摘要 | Allium chinense G. Don is a popular medicinal and aromatic plant, known as Ganoderma of vegetables in history for treating blood stasis syndrome that reduces red blood cell oxygen-carrying capacity and often causes severe brain damage. However, the effect of A. chinense on cerebral anoxia remains obscure. Here, the anti-hypoxic effect of A. chinense was investigated for the first time through the cerebral anoxia model of mice. Subsequent a bio-guided investigation brought about the isolation of 16 compounds, including 9 phenolic derivatives (2 new compounds (compound 1, 8) and one new natural product (compound 2), 4 steroidal saponins and 3 fatty acid monoglycerides, among which, 6 compounds (1-4, 7, 16) exhibited significant anoxia-tolerant activity in vitro. Moreover, the release of reactive oxygen species (ROS) was decreased significantly, and glutathione (GSH) and lactate dehydrogenase (LDH) were regulated by the 6 bioactive compounds in oxygen-glucose deprivation/ reoxygenation (OGD/R)-induced BV-2 cells damage. Besides that, protein expressions of HIF-1 alpha, NLRP3, COX-2, NF-kappa B p65 and IL-18 were suppressed effectively. The investigation provided a new nutritional strategy for A. chinense against cerebral anoxia and altitude illness, which might be partially mediated by downregulating NLRP3/NF-kappa B. |
| 学科主题 | Agriculture |
| WOS记录号 | WOS:000953271900001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75570]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Xiao,Xia,Liu,Yang-Yang,Yan,Xiao-Jun,et al. The protective effect of Allium chinense on anti-cerebral anoxia through regulating NLRP3/NF-?B[J]. INDUSTRIAL CROPS AND PRODUCTS,2023,196:116499. |
| APA | Xiao,Xia.,Liu,Yang-Yang.,Yan,Xiao-Jun.,Wang,Xiao-Na.,Hu,Bin-Yuan.,...&Luo,Xiao-Dong.(2023).The protective effect of Allium chinense on anti-cerebral anoxia through regulating NLRP3/NF-?B.INDUSTRIAL CROPS AND PRODUCTS,196,116499. |
| MLA | Xiao,Xia,et al."The protective effect of Allium chinense on anti-cerebral anoxia through regulating NLRP3/NF-?B".INDUSTRIAL CROPS AND PRODUCTS 196(2023):116499. |
入库方式： OAI收割
来源：昆明植物研究所
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