Ginsenoside Rg1 Delays Chronological Aging in a Yeast Model via CDC19-and SDH2-Mediated Cellular Metabolism
文献类型：期刊论文
| 作者 | S. M. Wang, J. H. Qiao, C. Y. Jiang, D. A. Pan, S. T. Yu, J. J. Chen, S. C. Liu, P. G. Zhang, D. Q. Zhao and M. C. Liu |
| 刊名 | Antioxidants
 |
| 出版日期 | 2023 |
| 卷号 | 12期号:2页码:20 |
| DOI | 10.3390/antiox12020296 |
| 英文摘要 | Ginsenosides, active substances in Panax ginseng C. A. Meyer (ginseng), extend lifespan in multiple species, ameliorate age-associated damage, and limit functional decline in multiple tissues. However, their active components and their molecular mechanisms are largely unknown. Here, ginsenoside Rg1 (Rg1) promoted longevity in Saccharomyces cerevisiae. Treatment with Rg1 decreased aging-mediated surface wrinkling, enhanced stress resistance, decreased reactive oxygen species' production and apoptosis, improved antioxidant enzyme activity, and decreased the aging rate. Proteomic analysis indicated that Rg1 delays S. cerevisiae senescence by regulating metabolic homeostasis. Protein-protein interaction networks based on differential protein expression indicated that CDC19, a homologue of pyruvate kinase, and SDH2, the succinate dehydrogenase iron-sulfur protein subunit, might be the effector proteins involved in the regulation by Rg1. Further experiments confirmed that Rg1 improved specific parameters of mitochondrial bioenergetics and core enzymes in the glycolytic pathway. Mutant strains were constructed that demonstrated the relationships between metabolic homeostasis and the predicted target proteins of Rg1. Rg1 could be used in new treatments for slowing the aging process. Our results also provide a useful dataset for further investigations of the mechanisms of ginseng in aging. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.ciomp.ac.cn/handle/181722/67960]  |
| 专题 | 中国科学院长春光学精密机械与物理研究所 |
| 推荐引用方式 GB/T 7714 | S. M. Wang, J. H. Qiao, C. Y. Jiang, D. A. Pan, S. T. Yu, J. J. Chen, S. C. Liu, P. G. Zhang, D. Q. Zhao and M. C. Liu. Ginsenoside Rg1 Delays Chronological Aging in a Yeast Model via CDC19-and SDH2-Mediated Cellular Metabolism[J]. Antioxidants,2023,12(2):20. |
| APA | S. M. Wang, J. H. Qiao, C. Y. Jiang, D. A. Pan, S. T. Yu, J. J. Chen, S. C. Liu, P. G. Zhang, D. Q. Zhao and M. C. Liu.(2023).Ginsenoside Rg1 Delays Chronological Aging in a Yeast Model via CDC19-and SDH2-Mediated Cellular Metabolism.Antioxidants,12(2),20. |
| MLA | S. M. Wang, J. H. Qiao, C. Y. Jiang, D. A. Pan, S. T. Yu, J. J. Chen, S. C. Liu, P. G. Zhang, D. Q. Zhao and M. C. Liu."Ginsenoside Rg1 Delays Chronological Aging in a Yeast Model via CDC19-and SDH2-Mediated Cellular Metabolism".Antioxidants 12.2(2023):20. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。