Amplifying oxidative stress utilizing multiband luminescence of lanthanide nanoparticles for eliciting systemic antitumor immunity
文献类型：期刊论文
| 作者 | F. Wu, H. Chen, Q. Li, R. Liu, Y. Suo, B. Li, X. Kong, Z. Cheng, H. Liu and Y. Chang |
| 刊名 | Chemical Engineering Journal
 |
| 出版日期 | 2023 |
| 卷号 | 468 |
| ISSN号 | 13858947 |
| DOI | 10.1016/j.cej.2023.143827 |
| 英文摘要 | Reactive oxygen species (ROS) are closely related to innate and adaptive immune responses in tumor immunotherapy. ROS-mediated therapies show great hope in improving therapeutic efficacy by inducing immunogenic cell death. However, the efficiency is still limited by the poor ROS production rate. Herein, a ROS nanogenerator is designed to boost antitumor immunity, integrating with pH-dissociable Fe3+-gallic acid (Fe-GA) complex as the shell and photosensitizer (Chlorin e6, Ce6)-coupled lanthanide-doped luminescence nanoparticles (LnNPs) as the core. Upon near-infrared (NIR) light irradiation, LnNPs exhibit multiband upconversion emission from ultraviolet (UV) to visible (Vis) and downshifting emission in the promising second NIR imaging region (NIR-II, 1550 nm). Especially, the UV photons and reducing agent GA could respectively mediate the reduction of Fe3+, allowing more Fe2+ to participate in the Fenton reaction to generate hydroxyl radicals (•OH) for ferroptosis therapy (FT). Besides, the UV–Vis upconversion emission can activate the coupling photosensitizer-Ce6 to generate 1O2 for photodynamic therapy (PDT). Additionally, Fe-GA can serve as a photothermal therapy (PTT) agent; in turn, hyperthermia enhances ROS generation. Our rational-designed Ln@Fe NPs could not only enhance the synergistic antitumor efficiency by boosting ROS generation but also effectively inhibit tumor metastasis by activating strong antitumor immunity, providing a paradigm for imaging-guided cancer treatment. © 2023 Elsevier B.V. |
| URL标识 | 查看原文 |
| 源URL | [http://ir.ciomp.ac.cn/handle/181722/68018]  |
| 专题 | 中国科学院长春光学精密机械与物理研究所 |
| 推荐引用方式 GB/T 7714 | F. Wu, H. Chen, Q. Li, R. Liu, Y. Suo, B. Li, X. Kong, Z. Cheng, H. Liu and Y. Chang. Amplifying oxidative stress utilizing multiband luminescence of lanthanide nanoparticles for eliciting systemic antitumor immunity[J]. Chemical Engineering Journal,2023,468. |
| APA | F. Wu, H. Chen, Q. Li, R. Liu, Y. Suo, B. Li, X. Kong, Z. Cheng, H. Liu and Y. Chang.(2023).Amplifying oxidative stress utilizing multiband luminescence of lanthanide nanoparticles for eliciting systemic antitumor immunity.Chemical Engineering Journal,468. |
| MLA | F. Wu, H. Chen, Q. Li, R. Liu, Y. Suo, B. Li, X. Kong, Z. Cheng, H. Liu and Y. Chang."Amplifying oxidative stress utilizing multiband luminescence of lanthanide nanoparticles for eliciting systemic antitumor immunity".Chemical Engineering Journal 468(2023). |
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