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Genetic polymorphisms in the 5-HT and endocannabinoid systems moderate the association between childhood trauma and burnout in the general occupational population

文献类型：期刊论文

作者Li, Yuling5,6,7,8,9; Wang, Lei1; He, Yingyi4; Zhu, Shuanggen3; He, Shu-Chang; Zhang, Xiang Yang2
刊名PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
出版日期2024-08-30
卷号134页码:10
关键词Burnout Serotonin (5-HT) HTR2A gene FAAH gene Childhood trauma
ISSN号0278-5846
DOI10.1016/j.pnpbp.2024.111054
通讯作者Zhu, Shuanggen(45353502@qq.com) ; He, Shu-Chang(shuchangh@pku.edu.cn) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn)
英文摘要Background: Interactions between the serotonin (5 -HT) and endocannabinoid (eCB) systems have been reported in the psychopathology of stress -related symptoms, while their interplay in regulating the relationship between childhood trauma and burnout remains unclear. In this study, we investigated the interaction of childhood trauma with genetic polymorphisms in these two systems in predicting burnout. Methods: Burnout, childhood trauma, and job stress were assessed using rating scales in 992 general occupational individuals. Genetic polymorphisms including HTR2A rs6313, 5-HTT rs6354 and FAAH rs324420, were genotyped. Linear hierarchical regression analysis and PROCESS macro in SPSS were used to examine two- and threeway interactions. Results: There were significant interactions of job stress x HTR2A rs6313 and childhood abuse x FAAH rs324420 on reduced personal accomplishment. Moreover, we found significant three-way interactions of childhood abuse x FAAH rs324420 x HTR2A rs6313 on cynicism and reduced personal accomplishment, childhood abuse x FAAH rs324420 x 5-HTT rs6354 on emotional exhaustion, and childhood neglect x FAAH rs324420 x 5-HTT rs6354 on reduced personal accomplishment. These results suggest that the FAAH rs324420 A allele carriers, when with some specific genetic polymorphisms of 5 -HT system, would show more positive associations between childhood trauma and burnout. Conclusions: Genetic polymorphisms in the 5 -HT and eCB systems may jointly moderate the impact of childhood trauma on burnout.
收录类别SCI
WOS关键词ACID AMIDE HYDROLASE ; SEROTONIN-2A RECEPTOR GENE ; RESILIENCE SCALE ; DORSAL RAPHE ; STRESS ; EXPRESSION ; CORTISOL ; BRAIN ; BDNF ; SUSCEPTIBILITY
资助项目National Natural Science Foundation of China[82,171,862] ; National Natural Science Foundation of China[82,371,884] ; Young Teachers Research Cultivation Foundation of South China Normal University[23KJ08]
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
语种英语
WOS记录号WOS:001259202100001
出版者PERGAMON-ELSEVIER SCIENCE LTD
资助机构National Natural Science Foundation of China ; Young Teachers Research Cultivation Foundation of South China Normal University
源URL[http://ir.psych.ac.cn/handle/311026/48410]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhu, Shuanggen; He, Shu-Chang; Zhang, Xiang Yang
作者单位1.Strateg Support Force Med Ctr, Dept Med Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Shenzhen Longhua Dist Cent Hosp, Dept Neurol, Shenzhen 518110, Peoples R China
4.Ohio State Univ, Coll Arts & Sci, Dept Psychol, Columbus, OH 43210 USA
5.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Beijing 100871, Peoples R China
6.Peking Univ, Sch Psychol & Cognit Sci, Beijing 100871, Peoples R China
7.South China Normal Univ, Guangdong Key Lab Mental Hlth & Cognit Sci, Guangzhou 510631, Peoples R China
8.South China Normal Univ, Inst Brain Res & Rehabil, Guangzhou 510631, Peoples R China
9.Minist Educ, Key Lab Brain Cognit & Educ Sci, Guangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Li, Yuling,Wang, Lei,He, Yingyi,et al. Genetic polymorphisms in the 5-HT and endocannabinoid systems moderate the association between childhood trauma and burnout in the general occupational population[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2024,134:10.
APA Li, Yuling,Wang, Lei,He, Yingyi,Zhu, Shuanggen,He, Shu-Chang,&Zhang, Xiang Yang.(2024).Genetic polymorphisms in the 5-HT and endocannabinoid systems moderate the association between childhood trauma and burnout in the general occupational population.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,134,10.
MLA Li, Yuling,et al."Genetic polymorphisms in the 5-HT and endocannabinoid systems moderate the association between childhood trauma and burnout in the general occupational population".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 134(2024):10.

入库方式： OAI收割

来源：心理研究所

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