Prevalence, demographic characteristics, and clinical features of suicide risk in first episode drug-na?ve schizophrenia patients with comorbid severe anxiety
文献类型：期刊论文
| 作者 | Ding, Mengjie4; Lang, Xiaoe3; Wang, Junhan4; Shangguan, Fangfang4; Zhang, Xiang -Yang1,2
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| 刊名 | JOURNAL OF PSYCHIATRIC RESEARCH
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| 出版日期 | 2024-08-01 |
| 卷号 | 176页码:232-239 |
| 关键词 | first episode drug -na & iuml Anxiety Suicide risk Depression Uric acid High -density lipoprotein cholesterol ve schizophrenia |
| ISSN号 | 0022-3956 |
| DOI | 10.1016/j.jpsychires.2024.06.018 |
| 通讯作者 | Shangguan, Fangfang(shanggff@cnu.edu.cn) ; Zhang, Xiang -Yang(zhangxy@psych.ac.cn) |
| 英文摘要 | Background: Both anxiety symptoms and suicide risk are common in schizophrenia. However, previous findings about the association between anxiety and suicide risk in schizophrenia were controversial. This study is the first to examine the prevalence of suicide risk and related demographic, clinical features in a large sample of first episode drug-na & iuml;ve (FEDN) schizophrenia patients with comorbid severe anxiety. Methods: In total, 316 patients with FEDN schizophrenia were enrolled in this study. Patients' symptoms were assessed using the Hamilton Depression Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS). Serum levels of glucose, insulin, uric acid, and lipids including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), were evaluated. Results: In the current study, 56.3% patients presented comorbid severe anxiety. The rate of suicide risk was higher in the severe anxiety group (55.6%) than in the mild-moderate anxiety group (33.3%). The interactions among severe anxiety, uric acid and HDL-C were associated with suicide risk. Compared with patients with normal uric acid, those with abnormal uric acid exhibited a stronger association between HAMA scores and HAMD-suicide item scores. This enhanced association was also observed for patients with abnormal HDL-C levels. Conclusions: In FEDN schizophrenia patients with comorbid severe anxiety, our findings suggested a high incidence of suicide risk. Abnormal levels of uric acid and low levels of HDL-C, as well as high depression may be associated with an increased risk of suicide in FEDN schizophrenia patients with comorbid severe anxiety. |
| 收录类别 | SCI |
| WOS关键词 | QUALITY-OF-LIFE ; MAJOR DEPRESSIVE DISORDER ; URIC-ACID LEVELS ; SYMPTOMS ; MORTALITY ; IDEATION ; PSYCHOSIS ; ANTIPSYCHOTICS ; ALLOPURINOL ; ASSOCIATION |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:001259080100001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.psych.ac.cn/handle/311026/48424]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Shangguan, Fangfang; Zhang, Xiang -Yang |
| 作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, Jinzhong 030000, Shanxi, Peoples R China 4.Capital Normal Univ, Sch Psychol, Key Lab Learning & Cognit, Beijing 100037, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Mengjie,Lang, Xiaoe,Wang, Junhan,et al. Prevalence, demographic characteristics, and clinical features of suicide risk in first episode drug-na?ve schizophrenia patients with comorbid severe anxiety[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2024,176:232-239. |
| APA | Ding, Mengjie,Lang, Xiaoe,Wang, Junhan,Shangguan, Fangfang,&Zhang, Xiang -Yang.(2024).Prevalence, demographic characteristics, and clinical features of suicide risk in first episode drug-na?ve schizophrenia patients with comorbid severe anxiety.JOURNAL OF PSYCHIATRIC RESEARCH,176,232-239. |
| MLA | Ding, Mengjie,et al."Prevalence, demographic characteristics, and clinical features of suicide risk in first episode drug-na?ve schizophrenia patients with comorbid severe anxiety".JOURNAL OF PSYCHIATRIC RESEARCH 176(2024):232-239. |
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来源：心理研究所
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