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Gender difference in the relationship between clinical symptoms, thyroid hormones, and metabolic parameters in young, first-episode and drug-na?ve major depressive disorder patients with suicide attempts: A network analysis perspective

文献类型：期刊论文

作者Shang, ZhaoXuan5; Fang, ChunQing5; Luo, GuoShuai4; Lang, XiaoE.3; Zhang, XianYang1,2
刊名JOURNAL OF PSYCHIATRIC RESEARCH
出版日期2024-08-01
卷号176页码:411-421
关键词Major depressive disorder Suicide attempts Gender difference Network analysis
ISSN号0022-3956
DOI10.1016/j.jpsychires.2024.06.042
通讯作者Zhang, XianYang(zhangxy@psych.ac.cn)
英文摘要Background: Suicide attempts are one of the most serious comorbidities in patients with major depressive disorder (MDD), and the prevalence of suicide attempts is higher in younger people compared to older people, with significant gender differences. This study aimed to investigate the relationship between suicide attempts, clinical symptoms, thyroid hormones, and metabolic parameters in young first-episode and drug-na & iuml;ve (FEND) MDD patients of different genders. Methods: A total of 1289 FEND MDD patients were recruited. Depression, anxiety, and psychotic symptoms were assessed using the Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), and the Positive and Negative Syndrome Scale (PANSS) positive subscale, respectively. Thyroid hormones and glucolipid metabolism indicators were also tested. Network analysis was employed to delineate the interplay between thyroid dysfunction, clinical symptoms, and metabolic disorders. Results: Among young FEND MDD patients, the rate of suicide attempts was 17.4% in males and 19.8% in females, showing no significant gender difference in the incidence of suicide attempts (chi 2 = 1.06, p = 0.303). In the network model, PANSS positive subscale (Expected Influence = 0.578) and HAMD scores (Expected Influence = 0.576) were identified as the individual symptoms that most affected male patients, whereas TSH (ThyroidStimulating Hormone) (Expected Influence = 0.972) and PANSS positive subscale (Expected Influence = 0.937) were identified as the individual symptoms that most affected female patients. In addition, we found that TSH (Expected Influence = 0.438) was a pivotal node connecting metabolic disturbances and clinical symptoms. Conclusion: Our findings emphasize the important role of psychotic symptoms in young MDD patients with suicide attempts. Moreover, our results highlight the pivotal role of serum TSH levels in the pathophysiology of young female MDD patients with suicide attempts.
收录类别SCI
WOS关键词SERUM-LIPID LEVELS ; RISK-FACTORS ; SUBCLINICAL HYPOTHYROIDISM ; MENTAL-DISORDERS ; ADULTS ; INDIVIDUALS ; ASSOCIATION ; THYROTROPIN ; PROFILE ; LEPTIN
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001264910000001
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://ir.psych.ac.cn/handle/311026/48453]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhang, XianYang
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Shanxi Med Univ, Dept Psychiat, Hosp 1, Taiyuan, Peoples R China
4.Tianjin Med Univ, Tianjin Anding Hosp, Inst Mental Hlth, Lab Biol Psychiat,Mental Hlth Ctr, Tianjin, Peoples R China
5.East China Normal Univ, Dept Psychol & Cognit Sci, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Shang, ZhaoXuan,Fang, ChunQing,Luo, GuoShuai,et al. Gender difference in the relationship between clinical symptoms, thyroid hormones, and metabolic parameters in young, first-episode and drug-na?ve major depressive disorder patients with suicide attempts: A network analysis perspective[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2024,176:411-421.
APA Shang, ZhaoXuan,Fang, ChunQing,Luo, GuoShuai,Lang, XiaoE.,&Zhang, XianYang.(2024).Gender difference in the relationship between clinical symptoms, thyroid hormones, and metabolic parameters in young, first-episode and drug-na?ve major depressive disorder patients with suicide attempts: A network analysis perspective.JOURNAL OF PSYCHIATRIC RESEARCH,176,411-421.
MLA Shang, ZhaoXuan,et al."Gender difference in the relationship between clinical symptoms, thyroid hormones, and metabolic parameters in young, first-episode and drug-na?ve major depressive disorder patients with suicide attempts: A network analysis perspective".JOURNAL OF PSYCHIATRIC RESEARCH 176(2024):411-421.

入库方式： OAI收割

来源：心理研究所

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