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Negative symptoms in treatment-resistant schizophrenia and its relationship with functioning

文献类型：期刊论文

作者Lui, Simon S. Y.5; Lam, Elson H. Y.4; Wang, Ling-ling1,2,3; Leung, Perry B. M.5; Cheung, Ezmond S. L.5; Wong, Christy H. Y.5; Zhan, Na5; Wong, Raisie W. K.5; Siu, Bonnie W. M.4; Tang, Dorothy Y. Y.4
刊名SCHIZOPHRENIA RESEARCH
出版日期2024-08-01
卷号270页码:459-464
关键词Treatment-resistant schizophrenia Negative symptoms Experiential pleasure Social functioning Cluster analysis
ISSN号0920-9964
DOI10.1016/j.schres.2024.07.008
通讯作者Lui, Simon S. Y.(lsy570@hku.hk) ; Chan, Raymond C. K.(rckchan@psych.ac.cn)
英文摘要Background: Recent operational criteria for treatment-resistant schizophrenia (TRS) recognized positive and negative symptoms. TRS patients may have heterogeneity in negative symptoms, but empirical data were lacking. We aimed to characterize TRS patients based on negative symptoms using cluster analysis, and to examine between-cluster differences in social functioning. Methods: We administered the Clinical Assessment Interview of Negative symptoms (CAINS), Brief Negative Symptom Scale (BNSS), the Positive and Negative Syndrome Scale (PANSS) and the Social and Occupational Functional Assessment (SOFAS to 126 TRS outpatients. All patients also completed the Temporal Experience of Pleasure Scale (TEPS), the Emotion Expressivity Scale (EES), and the Social Functional Scale (SFS). A two-stage hierarchical cluster analysis was performed with the CAINS, TEPS and EES as clustering variables. We validated the clusters using ANOVAs to compare group differences in the BNSS, PANSS, SOFAS and SFS. Results: Clustering indices supported a 3-cluster solution. Clusters 1 ( n = 46) and 3 ( n = 16) exhibited higher CAINS scores than Cluster 2 ( n = 64), and were negative-symptom TRS subtypes. Cluster 1 reported lower TEPS than Cluster 3; but Cluster 3 reported lower EES than Cluster 1. Upon validation, Clusters 1 and 3 exhibited higher BNSS scores than Cluster 2, but only Cluster 1 exhibited lower SOFAS and higher PANSS general symptoms than Cluster 2. Both Clusters 1 and 3 had higher self-report functioning than Cluster 2. Conclusion: We provided evidence for heterogeneity of negative symptoms in TRS. Negative symptoms can characterize TRS patients and predict functional outcome.
收录类别SCI
WOS关键词TREATMENT RESPONSE ; SCALE ; ANTIPSYCHOTICS ; VALIDATION ; ADJUSTMENT ; EXPERIENCE ; PLEASURE ; DEFICIT
资助项目HKU Seed Fund for PI Research - Basic Research[2202100748] ; Philip K. H. Wong Foundation
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001268555700001
出版者ELSEVIER
资助机构HKU Seed Fund for PI Research - Basic Research ; Philip K. H. Wong Foundation
源URL[http://ir.psych.ac.cn/handle/311026/48483]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Lui, Simon S. Y.; Chan, Raymond C. K.
作者单位1.Shanghai Normal Univ, Sch Psychol, Shanghai, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Castle Peak Hosp, Hong Kong, Peoples R China
5.Univ Hong Kong, Sch Clin Med, Dept Psychiat, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714		 Lui, Simon S. Y.,Lam, Elson H. Y.,Wang, Ling-ling,et al. Negative symptoms in treatment-resistant schizophrenia and its relationship with functioning[J]. SCHIZOPHRENIA RESEARCH,2024,270:459-464.
APA Lui, Simon S. Y..,Lam, Elson H. Y..,Wang, Ling-ling.,Leung, Perry B. M..,Cheung, Ezmond S. L..,...&Chan, Raymond C. K..(2024).Negative symptoms in treatment-resistant schizophrenia and its relationship with functioning.SCHIZOPHRENIA RESEARCH,270,459-464.
MLA Lui, Simon S. Y.,et al."Negative symptoms in treatment-resistant schizophrenia and its relationship with functioning".SCHIZOPHRENIA RESEARCH 270(2024):459-464.

入库方式： OAI收割

来源：心理研究所

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