Pan-cancer analysis identifies olfactory receptor family 7 subfamily A member 5 as a potential biomarker for glioma
文献类型：期刊论文
| 作者 | Bao, Yanqiu5; Tang, Ziqi4; Chen, Renli3; Yu, Xuebin3; Qi, Xuchen1,2 |
| 刊名 | PEERJ
 |
| 出版日期 | 2024-07-10 |
| 卷号 | 12页码:28 |
| 关键词 | Glioma Olfactory receptors Prognosis Biomarker |
| ISSN号 | 2167-8359 |
| DOI | 10.7717/peerj.17631 |
| 通讯作者 | Qi, Xuchen(qixuchen@zju.edu.cn) |
| 英文摘要 | Background. Human olfactory receptors (ORs) account for approximately 60% of all human G protein-coupled receptors. The functions of ORs extend beyond olfactory perception and have garnered significant attention in tumor biology. However, a comprehensive pan-cancer analysis of ORs in human cancers is lacking. Methods. Using data from public databases, such as HPA, TCGA, GEO, GTEx, TIMER2, TISDB, UALCAN, GEPIA2, and GSCA, this study investigated the role of olfactory receptor family 7 subfamily A member 5 (OR7A5) in various cancers. Functional analysis of OR7A5 in LGG and GBM was performed using the CGGA database. Molecular and cellular experiments were performed to validate the expression and biological function of OR7A5 in gliomas. Results. The results revealed heightened OR7A5 expression in certain tumors, correlating with the expression levels of immune checkpoints and immune infiltration. In patients with gliomas, the expression levels of OR7A5 were closely associated with adverse prognosis, 1p/19p co-deletion status, and wild-type IDH status. Finally, in vitro experiments confirmed the inhibitory effect of OR7A5 knockdown on the proliferative capacity of glioma cells and on the expression levels of proteins related to lipid metabolism. Conclusion. This study establishes OR7A5 as a novel biomarker, potentially offering a novel therapeutic target for gliomas. |
| 收录类别 | SCI |
| WOS关键词 | PROTEIN ; ACTIVATION ; EXPRESSION ; TARGETS ; 51E1 |
| 资助项目 | Shaoxing Municipal Science and Technology Plan Project of China[2022A14022] ; Shaoxing Health Science and Technology Project of China[2022KY003] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001268410600001 |
| 出版者 | PEERJ INC |
| 资助机构 | Shaoxing Municipal Science and Technology Plan Project of China ; Shaoxing Health Science and Technology Project of China |
| 源URL | [http://ir.psych.ac.cn/handle/311026/48475]  |
| 专题 | 心理研究所_健康与遗传心理学研究室 |
| 通讯作者 | Qi, Xuchen |
| 作者单位 | 1.Zhejiang Univ, Shaoxing Peoples Hosp, Shaoxing Hosp, Dept Neurosurg,Sch Med, Shaoxing, Zhejiang, Peoples R China 2.Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Neurosurg, Hangzhou, Zhejiang, Peoples R China 3.Shaoxing Peoples Hosp, Dept Neurosurg, Shaoxing, Zhejiang, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 5.Zhejiang Univ, Shaoxing Peoples Hosp, Shaoxing Hosp, Dept Med Res Ctr,Sch Med, Shaoxing, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bao, Yanqiu,Tang, Ziqi,Chen, Renli,et al. Pan-cancer analysis identifies olfactory receptor family 7 subfamily A member 5 as a potential biomarker for glioma[J]. PEERJ,2024,12:28. |
| APA | Bao, Yanqiu,Tang, Ziqi,Chen, Renli,Yu, Xuebin,&Qi, Xuchen.(2024).Pan-cancer analysis identifies olfactory receptor family 7 subfamily A member 5 as a potential biomarker for glioma.PEERJ,12,28. |
| MLA | Bao, Yanqiu,et al."Pan-cancer analysis identifies olfactory receptor family 7 subfamily A member 5 as a potential biomarker for glioma".PEERJ 12(2024):28. |
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来源：心理研究所
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