Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress
文献类型：期刊论文
| 作者 | Wang,Yin-Yuan; Ni,Jian-Cheng; Zhao,Yue-Qin; Yang,Xu; Niu,Zhen-Peng; Yang,Xing-Zhi; Dong,Xian-Xiang; Zhao,Yu-Han; Hao,Xiao-Jiang ; Ding,Xiao
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| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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| 出版日期 | 2023 |
| 关键词 | Iridoid glycosides Morinda officinalis lysosomal biogenesis TFEB/TFE3 antioxidant activity TRANSCRIPTIONAL CONTROL TFEB PHOSPHORYLATION REVEALS PATHWAY |
| ISSN号 | 1477-2213 |
| DOI | 10.1080/10286020.2023.2269370 |
| 英文摘要 | Morinda officinalis is a traditional Chinese tonic herb, and have been used in the treatment of multiple diseases. Here, three iridoid glycosides isolated from M. officinalis were evaluated for their roles in the autophagy-lysosomal pathway. All three iridoid glycosides could induce TFEB/TFE3-mediated lysosomal biogenesis and trigger autophagy. Interestingly, they promoted the nuclear import of TFEB/TFE3 without affecting their nuclear export, suggesting their role in the maintenance of lysosomal homeostasis. The results from this study shed light on the identification of autophagy activators from M. officinalis and provide a basis for developing them in the treatment of oxidative stress-involved diseases. |
| WOS记录号 | WOS:001099498200001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75611]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Wang,Yin-Yuan,Ni,Jian-Cheng,Zhao,Yue-Qin,et al. Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2023. |
| APA | Wang,Yin-Yuan.,Ni,Jian-Cheng.,Zhao,Yue-Qin.,Yang,Xu.,Niu,Zhen-Peng.,...&Ding,Xiao.(2023).Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH. |
| MLA | Wang,Yin-Yuan,et al."Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2023). |
入库方式： OAI收割
来源：昆明植物研究所
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