In vitro long-term antibacterial performance and mechanism of Zn-doped micro-arc oxidation coatings
文献类型：期刊论文
| 作者 | Liu, Yuzhi2; Chen, Changtian3; Liang, Tao2; Wang, Yaping2,3; Zhao, Rongfang3; Li, Guoqiang3; Bai, Chunguang4; Wu, Yuxi5; Yu, Fanglei1; Sheng, Liyuan6 |
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2024 |
| 卷号 | 233页码:11 |
| 关键词 | Titanium alloys Micro-arc oxidation Zn-doped coatings Antibacterial performance |
| ISSN号 | 0927-7765 |
| DOI | 10.1016/j.colsurfb.2023.113634 |
| 通讯作者 | Bai, Chunguang(cgbai@imr.ac.cn) ; Zhang, Rongfa(rfzhang-10@163.com) ; Zhao, Ying(ying.zhao@siat.ac.cn) |
| 英文摘要 | Micro-arc oxidation (MAO) coatings containing 2.86 wt%, 5.83 wt% and 8.81 wt% Zn (Zn-2.86 wt%, Zn-5.83 wt % and Zn-8.81 wt%) were separately fabricated on Ti6Al4V alloys using EDTA-ZnNa2 electrolytes. In vitro antibacterial examination exhibits that the antibacterial rates of Zn-2.86 wt%, Zn-5.83 wt% and Zn-8.81 wt% against Staphylococcus aureus (S. aureus) are 76.0 %, 100.0 % and 99.2 %, respectively. Reactive oxygen species (ROS) level of MAO samples is significantly higher than that of the untreated Ti6Al4V. Zn-containing coatings especially Zn-5.83 wt% induces the strongest oxidative stress on S. aureus due to relatively high released Zn2+ concentration. Moreover, qPCR analysis shows that MAO samples inhibit the icaADBC transcription and result in the down-regulation of PIA production, thereby mitigating biofilm formation. After immersion in simulated body fluid (SBF) for 3, 8 and 14 d, the antibacterial rate of Zn-5.83 wt% is 84.7 %, 63.2 % and 12.5 % respectively, and ROS level of MAO samples is also significantly higher than that of the untreated Ti6Al4V even after 14 d of immersion, suggesting that the antibacterial performance of MAO samples can last a relatively long immersion period and exhibit large application potential in orthopedic clinic. |
| 资助项目 | Open Project Program of Anhui Province Key Laboratory of Metallurgical Engineering & Resources Recycling (Anhui University of Technology)[JCYJ20210324120009026] ; Open Project Program of Anhui Province Key Laboratory of Metallurgical Engineering & Resources Recycling (Anhui University of Technology)[JCYJ20210324102013036] ; [SKF23-04] |
| WOS研究方向 | Biophysics ; Chemistry ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001112711300001 |
| 出版者 | ELSEVIER |
| 资助机构 | Open Project Program of Anhui Province Key Laboratory of Metallurgical Engineering & Resources Recycling (Anhui University of Technology) |
| 源URL | [http://ir.imr.ac.cn/handle/321006/177249]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Bai, Chunguang; Zhang, Rongfa; Zhao, Ying |
| 作者单位 | 1.Zhejiang Canwell Med Co Ltd, Jinhua 321000, Peoples R China 2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China 3.Jiangxi Sci & Technol Normal Univ, Sch Mat & Mech & Elect Engn, Nanchang 330013, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 5.Anhui Univ Technol, Key Lab Met Emiss Reduct & Resources Recycling, Minist Educ, Maanshan 243002, Peoples R China 6.Peking Univ, Shenzhen Inst, Shenzhen 518057, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yuzhi,Chen, Changtian,Liang, Tao,et al. In vitro long-term antibacterial performance and mechanism of Zn-doped micro-arc oxidation coatings[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2024,233:11. |
| APA | Liu, Yuzhi.,Chen, Changtian.,Liang, Tao.,Wang, Yaping.,Zhao, Rongfang.,...&Zhao, Ying.(2024).In vitro long-term antibacterial performance and mechanism of Zn-doped micro-arc oxidation coatings.COLLOIDS AND SURFACES B-BIOINTERFACES,233,11. |
| MLA | Liu, Yuzhi,et al."In vitro long-term antibacterial performance and mechanism of Zn-doped micro-arc oxidation coatings".COLLOIDS AND SURFACES B-BIOINTERFACES 233(2024):11. |
入库方式： OAI收割
来源：金属研究所
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