Amplification of oxidative stress by lipid surface-coated single-atom Au nanozymes for oral cancer photodynamic therapy
文献类型：期刊论文
| 作者 | Chan, Ming-Hsien1,4,5; Chen, Bo-Gu1; Li, Chien-Hsiu5; Huang, Wen-Tse1; Su, Ting-Yi1; Yin, Lichang3; Hsiao, Michael2,5; Liu, Ru-Shi1 |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2023-10-05 |
| 卷号 | 15期号:38页码:15558-15572 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/d3nr02088f |
| 通讯作者 | Yin, Lichang(lcyin@imr.ac.cn) ; Hsiao, Michael(mhsiao@gate.sinica.edu.tw) ; Liu, Ru-Shi(rsliu@ntu.edu.tw) |
| 英文摘要 | Single-atom nanozymes (SANs) are the latest trend in biomaterials research and promote the application of single atoms in biological fields and the realization of protein catalysis in vivo with inorganic nanoparticles. Carbon quantum dots (CDs) have excellent biocompatibility and fluorescence properties as a substrate carrying a single atom. It is difficult to break through pure-phase single-atom materials with quantum dots as carriers. In addition, there is currently no related research in the single-atom field in the context of oral cancer, especially head and neck squamous cell carcinoma. This research developed a lipid surface-coated nanozyme combined with CDs, single-atomic gold, and modified lipid ligands (DSPE-PEG) with transferrin (Tf) to treat oral squamous cell carcinoma. The study results have demonstrated that surface-modified single-atom carbon quantum dots (m-SACDs) exhibit excellent therapeutic effects and enable in situ image tracking for diagnosing and treating head and neck squamous carcinoma (HNSCC). Single-atom nanozymes (SANs) are the latest trend in biomaterials research and promote the application of single atoms in biological fields and the realization of protein catalysis in vivo with inorganic nanoparticles. |
| 资助项目 | This work was supported by a grant from the National Science and Technology Council in Taiwan (NSTC 109-2113-M-002-020-MY3) to Ru-Shi Liu. Genomics Research Center, Academia Sinica, supported this study with funding for Michael Hsiao. We thank beamlines 01 |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001066887100001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | This work was supported by a grant from the National Science and Technology Council in Taiwan (NSTC 109-2113-M-002-020-MY3) to Ru-Shi Liu. Genomics Research Center, Academia Sinica, supported this study with funding for Michael Hsiao. We thank beamlines 01 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/177680]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Yin, Lichang; Hsiao, Michael; Liu, Ru-Shi |
| 作者单位 | 1.Natl Taiwan Univ, Dept Chem, Taipei 10617, Taiwan 2.Natl Taiwan Univ, Dept & Grad Inst Vet Med, Sch Vet Med, Taipei 10617, Taiwan 3.Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Peoples R China 4.Natl Yang Ming Chiao Tung Univ, Dept Biomed Imaging & Radiol Sci, Taipei 11221, Taiwan 5.Acad Sinica, Genom Res Ctr, Taipei 11529, Taiwan |
| 推荐引用方式 GB/T 7714 | Chan, Ming-Hsien,Chen, Bo-Gu,Li, Chien-Hsiu,et al. Amplification of oxidative stress by lipid surface-coated single-atom Au nanozymes for oral cancer photodynamic therapy[J]. NANOSCALE,2023,15(38):15558-15572. |
| APA | Chan, Ming-Hsien.,Chen, Bo-Gu.,Li, Chien-Hsiu.,Huang, Wen-Tse.,Su, Ting-Yi.,...&Liu, Ru-Shi.(2023).Amplification of oxidative stress by lipid surface-coated single-atom Au nanozymes for oral cancer photodynamic therapy.NANOSCALE,15(38),15558-15572. |
| MLA | Chan, Ming-Hsien,et al."Amplification of oxidative stress by lipid surface-coated single-atom Au nanozymes for oral cancer photodynamic therapy".NANOSCALE 15.38(2023):15558-15572. |
入库方式： OAI收割
来源：金属研究所
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