Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation
文献类型：期刊论文
| 作者 | Zhao, Yanlong6; Qian, Yifu6; Wang, Haimang6; Zhao, Weiwei1,2,3,4,6; Zhao, Jing5; Zhang, Hongyu6 |
| 刊名 | ACS APPLIED POLYMER MATERIALS
 |
| 出版日期 | 2023-05-08 |
| 卷号 | 5期号:6页码:3999-4010 |
| 关键词 | bioinspired coating surface functionalization hydration lubrication antibacterial property anticoagulation |
| ISSN号 | 2637-6105 |
| DOI | 10.1021/acsapm.3c00234 |
| 通讯作者 | Zhang, Hongyu(zhanghyu@tsinghua.edu.cn) |
| 英文摘要 | Endowing the implanted biomaterial with a wide range of functions, such as lubrication and antibacterial and anticoagulation properties, is essential for their safe clinical use. In the present study, based on the superlubrication mechanism of articular cartilage, a branched polyelectrolyte polymer (PEI-PMPC) was successfully synthesized based on tert-butyl hydroperoxide-initiated grafting polymerization and then applied to the biocompatible polyurethane (PU) surface. Specifically, the PU sheet was pretreated by polydopamine (PDA), and the PEI-PMPC polymer was grafted onto the PDAmodified PU surface by Schiff base reaction to generate a solid PDA/ PEI-PMPC coating. The unmodified and modified surfaces were characterized by Fourier transform infrared spectroscopy, water contact angle, X-ray photoelectron spectroscopy, and surface zeta potential. To compare the lubrication, antibacterial behavior, and hemocompatibility, the relevant properties of the modified surfaces were evaluated by the tribological test, plate count method, surface morphology, hemolysis rate, activated partial thromboplastin time, and thrombin time. The experimental results demonstrated that the adhesion of bovine serum albumin, Escherichia coli, Staphylococcus aureus, platelets, and red blood cells was significantly decreased on the PEI-PMPC-modified PU surface compared with that of the unmodified PU surface. The multifunctional properties of the coating were attributed to the hydration layer formed by zwitterionic phosphorylcholine groups, and additionally, the cationic PEI served to kill the bacteria adhering to the surface. In summary, the bioinspired coating proposed in this study could potentially be used as a promising surface functionalization strategy for biomedical implants. |
| 资助项目 | National Natural Science Foundation of China[52022043] ; National Natural Science Foundation of China[52275199] ; Precision Medicine Foundation, Tsinghua University, China[10001020120] ; Capital's Funds for Health Improvement and Research[2020-2Z-40810] ; Research Fund of State Key Laboratory of Tribology, Tsinghua University, China[SKLT2022C18] |
| WOS研究方向 | Materials Science ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000988791900001 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Natural Science Foundation of China ; Precision Medicine Foundation, Tsinghua University, China ; Capital's Funds for Health Improvement and Research ; Research Fund of State Key Laboratory of Tribology, Tsinghua University, China |
| 源URL | [http://ir.imr.ac.cn/handle/321006/177955]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Zhang, Hongyu |
| 作者单位 | 1.Shandong Univ, Sch&Hosp Stomatol, Cheeloo Coll Med, Jinan 250012, Shandong, Peoples R China 2.Shandong Univ, Shandong Key Lab Oral Tissue Regenerat, Jinan 250012, Shandong, Peoples R China 3.Shandong Univ, Shandong Engn Lab Dent Mat & Oral Tissue Regenerat, Jinan 250012, Shandong, Peoples R China 4.Shandong Univ, Shandong Prov Clin Res Ctr Oral Dis, Jinan 250012, Shandong, Peoples R China 5.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 6.Tsinghua Univ, Dept Mech Engn, State Key Lab Tribol Adv Equipment, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Yanlong,Qian, Yifu,Wang, Haimang,et al. Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation[J]. ACS APPLIED POLYMER MATERIALS,2023,5(6):3999-4010. |
| APA | Zhao, Yanlong,Qian, Yifu,Wang, Haimang,Zhao, Weiwei,Zhao, Jing,&Zhang, Hongyu.(2023).Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation.ACS APPLIED POLYMER MATERIALS,5(6),3999-4010. |
| MLA | Zhao, Yanlong,et al."Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation".ACS APPLIED POLYMER MATERIALS 5.6(2023):3999-4010. |
入库方式： OAI收割
来源：金属研究所
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