Phosphorus magnesium fiber regulates macrophage polarization through TRPM7 to accelerate wound healing
文献类型：期刊论文
| 作者 | Wei, Xuebo7; Liao, Zhiyong7; Yang, Liangliang1; Wu, Fangfang2,6; Chen, Shaodong5; Shao, Chuxiao5; Wang, Xin4; Xiao, Keshen3; Xiao, Jian1; Xu, Ke7 |
| 刊名 | APPLIED MATERIALS TODAY
 |
| 出版日期 | 2023-04-01 |
| 卷号 | 31页码:12 |
| 关键词 | Wound healing Phosphorus magnesium fiber Macrophage polarization TRPM7 channel |
| ISSN号 | 2352-9407 |
| DOI | 10.1016/j.apmt.2023.101758 |
| 通讯作者 | Xu, Ke(godxu1987@wzu.edu.cn) ; Sun, Da(sunday@wzu.edu.cn) ; Zhang, Hongyu(hyzhang@wmu.edu.cn) |
| 英文摘要 | Wound healing is a complex process that can be delayed by persistent inflammatory responses after trauma. Many studies have found that in situ application of biomaterials releases metal ions into wounds to promote wound healing, but the underlying mechanism has not been elucidated. Therefore, we developed a novel nanoscale functional material, phosphorus magnesium fiber (PMF), as a wound dressing to explore its association with wound healing. In this study, in vivo wound healing results showed that PMF accelerated wound closure in full-thickness wound animal models, accompanied by collagen deposition and granulation formation. Moreover, PMF accelerated macrophage polarization by regulating TRPM7-ERK1/2 signaling through the long-term release of magnesium ions into the wound, which contributes to enhancing cell proliferation, growth factor production, and synthesis of ECM in the wound bed, ultimately facilitating wound healing. In vitro studies revealed that PMF promoted the polarization of macrophages to the anti-inflammatory M2 phenotype. Meanwhile, PMF upregulated TRPM7-ERK1/2 expression. In conclusion, our study confirmed the relationship between PMF and macrophage behavior mediated by the TRPM7 channel protein and subsequently investigated the function of PMF in wound healing. This magnesium-based nanofiber material offers an innovative method for treating open wounds and is anticipated to be used as a wound dressing in the field of tissue regeneration. |
| 资助项目 | National Natural Science Foundation of China[51901160] ; Zhejiang Provincial Natural Science Foundation of China[LQ22H150004] ; Zhejiang Provincial Natural Science Foundation of China[LY19H030004] ; Lishui City Science and Technology Project[2022GYX30] ; Wenzhou Science and Technology Innovation Project[ZY2020023] ; Wenzhou Science and Technology Innovation Project[ZY2020026] ; Ningbo Key Research and Development Program[2022Z146] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000995158500001 |
| 出版者 | ELSEVIER |
| 资助机构 | National Natural Science Foundation of China ; Zhejiang Provincial Natural Science Foundation of China ; Lishui City Science and Technology Project ; Wenzhou Science and Technology Innovation Project ; Ningbo Key Research and Development Program |
| 源URL | [http://ir.imr.ac.cn/handle/321006/178099]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Xu, Ke; Sun, Da; Zhang, Hongyu |
| 作者单位 | 1.Wenzhou Med Univ, Cixi Biomed Res Inst, Sch Pharmaceut Sci, Wenzhou Wound Repair & Regenerat Key Lab, Wenzhou, Zhejiang, Peoples R China 2.Wenzhou Med Univ, Affiliated Hosp 2, Dept Emergency, Wenzhou, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang, Peoples R China 4.Ningbo NO6 Hosp, Dept Plast & Reconstruct Surg, Hand & Microsurg, Ningbo, Zhejiang, Peoples R China 5.Lishui Peoples Hosp, Dept Orthopaed, Lishui, Zhejiang, Peoples R China 6.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China 7.Wenzhou Univ, Coll Life & Environm Sci, Wenzhou, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Xuebo,Liao, Zhiyong,Yang, Liangliang,et al. Phosphorus magnesium fiber regulates macrophage polarization through TRPM7 to accelerate wound healing[J]. APPLIED MATERIALS TODAY,2023,31:12. |
| APA | Wei, Xuebo.,Liao, Zhiyong.,Yang, Liangliang.,Wu, Fangfang.,Chen, Shaodong.,...&Zhang, Hongyu.(2023).Phosphorus magnesium fiber regulates macrophage polarization through TRPM7 to accelerate wound healing.APPLIED MATERIALS TODAY,31,12. |
| MLA | Wei, Xuebo,et al."Phosphorus magnesium fiber regulates macrophage polarization through TRPM7 to accelerate wound healing".APPLIED MATERIALS TODAY 31(2023):12. |
入库方式： OAI收割
来源：金属研究所
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