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Upconversion nanoparticles@single-walled carbon nanotubes composites as efficient self-monitored photo-thermal agents

文献类型：期刊论文

作者Xu, Yang5; Zou, Mengke1,6; Wang, Hong5; Zhang, Lili6; Xing, Mingming5; He, Maoshuai2; Jiang, Hua3; Zhang, Qiang4; Xin, Fangyun5; Tian, Ying5
刊名SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
出版日期2023-12-15
卷号303页码:8
关键词Upconversion nanoparticles Single -walled carbon nanotubes Nanocomposite Hyperthermia Temperature sensing
ISSN号1386-1425
DOI10.1016/j.saa.2023.123173
通讯作者Xin, Fangyun(xin_2020@dlmu.edu.cn) ; Tian, Ying(tianying@dlmu.edu.cn)
英文摘要Conventional photothermal therapy (PTT) usually relies on a macroscopic heat source to raise the temperature of tissues to 41-45 degrees C, which not only kills the pathological cells but causes severe side effects on nearby normal tissues, thus reducing the accuracy of PTT. Here we successfully fabricated nanocomposites of NaYF4:Yb3+, Tm3+@NaYF4:Yb3+@SiO2-SWCNTs, in which the upconversion nanoparticles (UCNPs) serve as real-time temperature-feedback moiety and the single-walled carbon nanotubes (SWCNTs) serve as efficient nano-heaters. The sample displays an excellent photothermal conversion capacity, i.e., the temperature of the aqueous dispersion increases from 23.3 degrees C up to 60.1 degrees C under 980 nm excitation due to the intense absorption and highly efficient heat generation of SWCNTs. Meanwhile, the temperature of the nanocomposites is monitored in real time based on the fluorescent intensity ratio of UCNPs. The in-vitro experiments demonstrate that the temperature of the nanocomposites at tissue injection of 1 mm can reach PTT temperature of 42.2 degrees C with a facile surrounding temperature of 36.2 degrees C under moderate laser power (980 nm, 2.0 W cm-2). These results provide a novel design for multifunctional nanocomposites that enable safe and controlled PTT.
资助项目National Natural Science Foundation of China[11504039] ; National Natural Science Foundation of China[3132023193] ; Fundamental Research Funds for the Central Universities ; [12004063]
WOS研究方向Spectroscopy
语种英语
WOS记录号WOS:001058572300001
出版者PERGAMON-ELSEVIER SCIENCE LTD
资助机构National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities
源URL[http://ir.imr.ac.cn/handle/321006/178999]  
专题金属研究所_中国科学院金属研究所
通讯作者Xin, Fangyun; Tian, Ying
作者单位1.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China
2.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China
3.Aalto Univ, Sch Sci, Dept Appl Phys, Puumiehenkuja 2, Aalto 00076, Finland
4.Honda Res Inst Inc, 70 Rio Robles, San Jose, CA 95134 USA
5.Dalian Maritime Univ, Sch Sci, Dalian 116026, Peoples R China
6.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Yang,Zou, Mengke,Wang, Hong,et al. Upconversion nanoparticles@single-walled carbon nanotubes composites as efficient self-monitored photo-thermal agents[J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,2023,303:8.
APA Xu, Yang.,Zou, Mengke.,Wang, Hong.,Zhang, Lili.,Xing, Mingming.,...&Tian, Ying.(2023).Upconversion nanoparticles@single-walled carbon nanotubes composites as efficient self-monitored photo-thermal agents.SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,303,8.
MLA Xu, Yang,et al."Upconversion nanoparticles@single-walled carbon nanotubes composites as efficient self-monitored photo-thermal agents".SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 303(2023):8.

入库方式： OAI收割

来源：金属研究所

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