Stereochemical insights into enantioselective antiplasmodial lignanamides from the twigs and leaves of Solanum erianthum
文献类型：期刊论文
| 作者 | Liu, Xi-Hong2,3; Qian, Yu-Nan1; Xie, Zhi-Xiang2,3; Tian, Peng-Hai1; Huang, Zheng-Hui1; Zhou, Bin2; Yue, Jian-Min2,3
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| 刊名 | PHYTOCHEMISTRY
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| 出版日期 | 2024-08-01 |
| 卷号 | 224页码:8 |
| 关键词 | Solanum erianthum Solanaceae Lignanamides Chiral resolution Enantiomers Antiplasmodial activity |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2024.114163 |
| 通讯作者 | Zhou, Bin(zbbrush@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Stereochemical investigations on the twigs and leaves of Solanum erianthum afforded five pairs of lignanamide enantiomers and a previously undescribed phenolic amide ( 3 ). Particularly, two pairs of previously undescribed lignanamide racemates ( 1a/1b - 2a/2b ) represent the first case of natural products that feature an unreported 5/ 5-fused N / O -biheterocyclic core. Their structures, including the absolute configurations, were determined unambiguously by using spectroscopic analyses and electronic circular dichroism calculations. A speculative biogenetic pathway for 1 - 3 was proposed. Interestingly, these lignanamides exhibited enantioselective antiplasmodial activities against drug-sensitive Plasmodium falciparum 3D7 strain and chloroquine-resistant Plasmodium falciparum Dd2 strain, pointing out that chirality plays an important role in drug development. |
| WOS关键词 | FRUITS ; CONSTITUENTS ; PLANTS ; GLYCOSIDES |
| 资助项目 | National Natural Science Foundation of China[82322064] ; National Natural Science Foundation of China[82293685] ; National Natural Science Foundation of China[82202551] ; Youth Inno- vation Promotion Association of CAS[2022283] ; Youth Inno- vation Promotion Association of CAS[2023290] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001249472100001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311905]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhou, Bin; Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Immun & Infect, Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xi-Hong,Qian, Yu-Nan,Xie, Zhi-Xiang,et al. Stereochemical insights into enantioselective antiplasmodial lignanamides from the twigs and leaves of Solanum erianthum[J]. PHYTOCHEMISTRY,2024,224:8. |
| APA | Liu, Xi-Hong.,Qian, Yu-Nan.,Xie, Zhi-Xiang.,Tian, Peng-Hai.,Huang, Zheng-Hui.,...&Yue, Jian-Min.(2024).Stereochemical insights into enantioselective antiplasmodial lignanamides from the twigs and leaves of Solanum erianthum.PHYTOCHEMISTRY,224,8. |
| MLA | Liu, Xi-Hong,et al."Stereochemical insights into enantioselective antiplasmodial lignanamides from the twigs and leaves of Solanum erianthum".PHYTOCHEMISTRY 224(2024):8. |
入库方式： OAI收割
来源：上海药物研究所
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