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Enhanced ophthalmic bioavailability and stability of atropine sulfate via sustained release particles using polystyrene sulfonate resin

文献类型：期刊论文

作者Li, Falan2,3,5; Ye, Xinyue2,3,5; Li, Mingwei2,3,5; Nie, Qin4; Wang, Huihui2,3; Zhang, Guoqing2; Dong, Liyun2,3,5; Wang, Caifen4; Wu, Li4; Liu, Hongfei1,2
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
出版日期2024-07-20
卷号660页码:10
关键词Atropine sulfate Sodium polystyrene sulfonate resin Sustained-release Bioavailability Mean residence time Stability Myopia
ISSN号0378-5173
DOI10.1016/j.ijpharm.2024.124294
通讯作者Liu, Hongfei(hml19970522@163.com) ; Wang, Lifeng(22914692@qq.com) ; Peng, Can(pengcan@ahtcm.edu.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn)
英文摘要Atropine sulfate (ATS) eye drops at low concentrations constitute a limited selection for myopia treatment, with challenges such as low ophthalmic bioavailability and inadequate stability. This study proposes a novel strategy by synthesizing ophthalmic sodium polystyrene sulfonate resin (SPSR) characterized by a spherical shape and uniform size for cationic exchange with ATS. The formulation of ATS@SPSR suspension eye drops incorporates xanthan gum and hydroxypropyl methylcellulose (HPMC) as suspending agents. In vitro studies demonstrated that ATS@SPSR suspension eye drops exhibited sustained release characteristics, and tropic acid, its degradation product, remained undetected for 30 days at 40 degrees C. The ATS levels in the tear fluids and aqueous humor of New Zealand rabbits indicated a significant increase in mean residence time (MRT) and area under the drug concentration-time curve (AUC0-12 h) for ATS@SPSR suspension eye drops compared to conventional ATS eye drops. Moreover, safety assessment confirmed the non-irritating nature of ATS@SPSR suspension eye drops in rabbit eyes. In conclusion, the cation-responsive sustained-release ATS@SPSR suspension eye drops enhanced the bioavailability and stability of ATS, offering a promising avenue for myopia treatment.
WOS关键词ION-EXCHANGE-RESIN ; HYDROXYPROPYL-BETA-CYCLODEXTRIN ; MYOPIA PROGRESSION ; CHILDHOOD MYOPIA ; DRUG-DELIVERY ; EYE DROPS ; SUSPENSION ; FORMULATION ; PREVALENCE ; NANOCERIA
资助项目National Natural Science Foundation of China[82273863]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001250403700001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/311908]  
专题中国科学院上海药物研究所
通讯作者Liu, Hongfei; Wang, Lifeng; Peng, Can; Zhang, Jiwen
作者单位1.JiangSu Univ, Zhenjiang 212000, Peoples R China
2.Jiangsu Yungou Pharmaceut Technol Co Ltd, Nantong 226126, Peoples R China
3.Yangtze Delta Drug Adv Res Inst, Nantong 226133, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China
5.Anhui Univ Chinese Med, Coll Pharm, Hefei 230012, Peoples R China
推荐引用方式
GB/T 7714		 Li, Falan,Ye, Xinyue,Li, Mingwei,et al. Enhanced ophthalmic bioavailability and stability of atropine sulfate via sustained release particles using polystyrene sulfonate resin[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2024,660:10.
APA Li, Falan.,Ye, Xinyue.,Li, Mingwei.,Nie, Qin.,Wang, Huihui.,...&Zhang, Jiwen.(2024).Enhanced ophthalmic bioavailability and stability of atropine sulfate via sustained release particles using polystyrene sulfonate resin.INTERNATIONAL JOURNAL OF PHARMACEUTICS,660,10.
MLA Li, Falan,et al."Enhanced ophthalmic bioavailability and stability of atropine sulfate via sustained release particles using polystyrene sulfonate resin".INTERNATIONAL JOURNAL OF PHARMACEUTICS 660(2024):10.

入库方式： OAI收割

来源：上海药物研究所

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