Crotonoids A-H, Labdane-Type Diterpenoids with Anti-Inflammatory Activity from Croton Sublyratus
文献类型：期刊论文
| 作者 | Qi, Jing-Jing2,3; Li, Ying1; Fu, Rui-Yao2,3; Liu, Qun-Fang3 ; Zhao, Jin-Xin1,3; Yue, Jian-Min1,2,3
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2024-06-22 |
| 页码 | 10 |
| 关键词 | Croton sublyratus labdane-type diterpenoids norditerpenoids anti-inflammatory nitric oxide |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202401089 |
| 通讯作者 | Zhao, Jin-Xin(jxzhao@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Croton sublyratus (Euphorbiaceae) is a traditional medicinal plant used by the Thai populace to treat helminthic infections and dermatologic conditions. In present study, eight new labdane-type diterpenoids, crotonoids A-H (1-8) and one known analogue (9) were isolated from the aerial parts of C. sublyratus. Compounds 6 and 7 belong to the rare class of 14,15-dinor-labdane diterpenoids. Compound 8 exhibited a rare 14,15,17-trinor-labdane skeleton. The structures of all these diterpenoids were elucidated by spectroscopic data analysis, electronic circular dichroism calculations, and single-crystal X-ray diffraction analysis. Compound 9 exhibited moderate anti-inflammatory activity via the inhibition of NO production in lipopolysaccharide-induced RAW 264.7 cells. |
| 资助项目 | National Key Research and Development Program of China ; National Natural Science Foundation of China[22237007] ; National Natural Science Foundation of China[T2192972] ; Youth Innovation Promotion Association of Chinese Academy of Sciences (CAS)[2022282] ; [2023YFE0206100] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001252786400001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311923]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhao, Jin-Xin; Yue, Jian-Min |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, 198 East Binhai Rd, Yantai 264117, Shandong, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Rd, Nanjing 210023, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Jing-Jing,Li, Ying,Fu, Rui-Yao,et al. Crotonoids A-H, Labdane-Type Diterpenoids with Anti-Inflammatory Activity from Croton Sublyratus[J]. CHEMISTRY & BIODIVERSITY,2024:10. |
| APA | Qi, Jing-Jing,Li, Ying,Fu, Rui-Yao,Liu, Qun-Fang,Zhao, Jin-Xin,&Yue, Jian-Min.(2024).Crotonoids A-H, Labdane-Type Diterpenoids with Anti-Inflammatory Activity from Croton Sublyratus.CHEMISTRY & BIODIVERSITY,10. |
| MLA | Qi, Jing-Jing,et al."Crotonoids A-H, Labdane-Type Diterpenoids with Anti-Inflammatory Activity from Croton Sublyratus".CHEMISTRY & BIODIVERSITY (2024):10. |
入库方式： OAI收割
来源：上海药物研究所
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