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Controlled release of vitamin A palmitate from crosslinked cyclodextrin organic framework for dry eye disease therapy

文献类型：期刊论文

作者Ye, Xinyue3,4,6; Li, Falan3,4,6; Li, Mingwei3,4,6; Zhang, Guoqing3; Wang, Weixing2; Wang, Zhigang2; Zhang, Hui3,4,6; Dong, Liyun3,4,6; Lin, Xueyuan4; Wu, Li4,5
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
出版日期2024-06-25
卷号659页码:11
关键词Crosslinked cyclodextrin organic frameworks Vitamin A palmitate Suspension eye drops Controlled release Dry eye disease
ISSN号0378-5173
DOI10.1016/j.ijpharm.2024.124279
通讯作者Peng, Can(pengcan@ahtcm.edu.cn) ; Wang, Lifeng(wdchen@ahtcm.edu.cn) ; Chen, Weidong(wdchen@ahtcm.edu.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn)
英文摘要Controlled release drug delivery systems of eye drops are a promising ophthalmic therapy with advantages of good patient compliance and low irritation. However, the lack of a suitable drug carrier for ophthalmic use limits the development of the aforementioned system. Herein, the crosslinked cyclodextrin organic framework (COF) with a cubic porous structure and a uniform particle size was synthesized and applied to solidify vitamin A palmitate (VAP) by using the solvent-free method. The VAP@COF suspension eye drops were formulated by screening co-solvents, suspending agents, and stabilizing agents to achieve a homogeneous state and improve stability. According to the in vitro release study, the VAP@COF suspension exhibited a controlled release of VAP within 12 h. Both the ex vivo corneal contact angle and in vivo fluorescence tracking indicated that the VAP@COF suspension prolonged the VAP residence time on the ocular surface. This suspension accelerated the recovery of the dry eye disease (DED) model in New Zealand rabbits. Furthermore, the suspension was non-cytotoxic to human corneal epithelial cells and non-irritation to rabbit eyes. In summary, the particulate COF is an eyeacceptable novel carrier that sustains release and prolongs the VAP residence time on the ocular surface for DED treatment.
WOS关键词LIQUID-CRYSTALLINE NANOPARTICLES ; DRUG-DELIVERY SYSTEMS ; EFFICACY ; BIOAVAILABILITY ; FORMULATIONS ; SOLUBILITY ; RETENTION ; STABILITY ; NANOCERIA ; ANTERIOR
资助项目National Natural Science Foundation of China[82273863]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001248321000002
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/311929]  
专题中国科学院上海药物研究所
通讯作者Peng, Can; Wang, Lifeng; Chen, Weidong; Zhang, Jiwen
作者单位1.Jiangxi Univ Chinese Med, Nanchang 330004, Jiangxi, Peoples R China
2.Nantong Haimen Peoples Hosp, Nantong 226199, Peoples R China
3.Jiangsu Yunshi Pharmaceut Technol Co, Nantong 226133, Peoples R China
4.Yangtze Delta Drug Adv Res Inst, Nantong 226133, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China
6.Anhui Univ Chinese Med, Hefei 230012, Peoples R China
推荐引用方式
GB/T 7714		 Ye, Xinyue,Li, Falan,Li, Mingwei,et al. Controlled release of vitamin A palmitate from crosslinked cyclodextrin organic framework for dry eye disease therapy[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2024,659:11.
APA Ye, Xinyue.,Li, Falan.,Li, Mingwei.,Zhang, Guoqing.,Wang, Weixing.,...&Zhang, Jiwen.(2024).Controlled release of vitamin A palmitate from crosslinked cyclodextrin organic framework for dry eye disease therapy.INTERNATIONAL JOURNAL OF PHARMACEUTICS,659,11.
MLA Ye, Xinyue,et al."Controlled release of vitamin A palmitate from crosslinked cyclodextrin organic framework for dry eye disease therapy".INTERNATIONAL JOURNAL OF PHARMACEUTICS 659(2024):11.

入库方式： OAI收割

来源：上海药物研究所

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