Effect of guidewire on the accuracy of trans-stenotic pressure measurement-A computational study
文献类型：期刊论文
| 作者 | Wang, Junjie7; Hao ZZ(郝占宙)5,6 ; Yin B(银波)5,6; Tan, Wenchang2,3,4,7; Zhu, Chi1,7
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| 刊名 | PHYSICS OF FLUIDS
 |
| 出版日期 | 2024 |
| 卷号 | 36期号:1页码:16 |
| ISSN号 | 1070-6631 |
| DOI | 10.1063/5.0180162 |
| 通讯作者 | Tan, Wenchang(tanwch@pku.edu.cn) ; Zhu, Chi(chi.zhu@pku.edu.cn) |
| 英文摘要 | Accurate measurement of trans-stenotic pressure drop is vital for risk stratification in coronary artery disease. Currently, in vivo pressure measurement relies mostly on a pressure guidewire inserted into the artery, which inevitably alters local hemodynamics. To precisely assess the impact of guidewire insertion on the accuracy of pressure measurement, this study conducts numerical simulations with both an idealized straight-tube model and a patient-specific model. Results with and without a guidewire model are compared and analyzed. Results from the idealized model reveal that the insertion of a guidewire shifts velocity distribution, increases resistance, and amplifies the pressure drop across the stenosis. The patient-specific model also demonstrates that the guidewire causes non-negligible flow redistribution among the arterial branches, but the influence on pressure drop remains mostly localized. An analytical model for trans-stenotic pressure drop that takes the guidewire into consideration is also proposed and validated against the 3D simulation results. It is observed that the maximum relative error is around 3.0% in the patient-specific model, indicating the effectiveness of the analytical model in physiologically accurate settings. The proposed model can be used to align computed tomography-derived fractional flow reserve values with clinically recognized FFR standards established through guidewire measurements. |
| 分类号 | 一类/力学重要期刊 |
| WOS关键词 | FRACTIONAL FLOW RESERVE ; IN-VITRO VALIDATION ; BLOOD-FLOW ; ARTERIAL STENOSES ; CORONARY ; HEMODYNAMICS ; ANEURYSMS ; VELOCITY ; MODELS ; SIMULATIONS |
| 资助项目 | National Key Research and Development Program of China[2021YFA1000200] ; National Key Research and Development Program of China[2021YFA1000201] ; Fundamental Research Funds for the Central Universities, Peking University[BYESS2023025] ; Young Elite Scientists Sponsorship Program by BAST[KQTD20180411143400981] ; Shenzhen Science and Technology RD Grant |
| WOS研究方向 | Mechanics ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001261448800018 |
| 资助机构 | National Key Research and Development Program of China ; Fundamental Research Funds for the Central Universities, Peking University ; Young Elite Scientists Sponsorship Program by BAST ; Shenzhen Science and Technology RD Grant |
| 其他责任者 | Tan, Wenchang ; Zhu, Chi |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/96142]  |
| 专题 | 力学研究所_流固耦合系统力学重点实验室(2012-) |
| 作者单位 | 1.Peking Univ, Nanchang Innovat Inst, Nanchang, Peoples R China 2.Shenzhen Bay Lab, Shenzhen, Guangdong, Peoples R China; 3.Peking Univ, Shenzhen Grad Sch, Shenzhen, Guangdong, Peoples R China; 4.PKU HKUST Shenzhen Hong Kong Inst, Shenzhen, Guangdong, Peoples R China; 5.Chinese Acad Sci, Inst Mech, Key Lab Mech Fluid Solid Coupling Syst, Beijing, Peoples R China; 6.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China; 7.Peking Univ, Dept Mech & Engn Sci, Beijing, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Junjie,Hao ZZ,Yin B,et al. Effect of guidewire on the accuracy of trans-stenotic pressure measurement-A computational study[J]. PHYSICS OF FLUIDS,2024,36(1):16. |
| APA | Wang, Junjie,郝占宙,银波,Tan, Wenchang,&Zhu, Chi.(2024).Effect of guidewire on the accuracy of trans-stenotic pressure measurement-A computational study.PHYSICS OF FLUIDS,36(1),16. |
| MLA | Wang, Junjie,et al."Effect of guidewire on the accuracy of trans-stenotic pressure measurement-A computational study".PHYSICS OF FLUIDS 36.1(2024):16. |
入库方式： OAI收割
来源：力学研究所
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