Soil disintegration is a key process of the early stages of soil erosion. The water level fluctuation zone (WLFZ) in reservoirs undergoes seasonal changes involving periodic alternations in inundation and exposure that can affect soil disintegration. In this study, we conducted experiments on pre-wetted undisturbed soil samples obtained from different elevations ranging from 155 to 180 m a.s.l. and different soil depths (0-10 and 10-20 cm) in the WLFZ of the Three Gorges Reservoir (TGR), upper Yangtze River, China. We investigated how soil disintegration varies depending on elevation within the WLFZ and used principal component analysis (PCA) and stepwise regression to identify the dominant variables affecting soil disintegration. Results show the following: (1) The disintegration ratio, which is a measure of the amount of soil disintegration that occurs during experiments, varied in the range of 0.45 %-4.79 % over 60 min, with 79 %-100 % of the disintegration occurring within the first 30 min. The disintegration ratio increases with decreasing elevation in the WLFZ. Soil samples from a depth of 0-10 cm disintegrated 0.43 % less on average than those from a depth of 10-20 cm. The relationship between disintegration rate and elevation can be expressed using an exponential function with R-2 > 0.80. (2) The main variables loading onto the first three principal components (explain 91.4 % of the variation in all variables) identified by PCA were those involving soil aggregates, the plant root system, and soil particle-size, respectively. (3) Stepwise regression identified >0.25 mm water-stable aggregate content (W-s0.25) and root mean diameter (D-root) as the strongest predictors of soil disintegration and yielded a linear regression equation with R-2 = 0.88. W-s0.25 and D-root were the most influential variables on the elevation-dependent occurrence/degree of disintegration. Such information is essential for understanding the occurrence and prevention of bank erosion in reservoir areas.