Metabolomics perspectives into the co-exposure effect of polycyclic aromatic hydrocarbons and metals on renal function: A meet-in-the-middle approach
文献类型：期刊论文
| 作者 | Liao, Qilong2,3; Huang, Lulu1,3; Cai, Fengshan3; Luo, Weikeng3; Li, Min3; Yang, Juanjuan1,3; Tang, Bin3,5; Xiao, Xinyi3,4; Yan, Xiao3; Zheng, Jing1,3 |
| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
 |
| 出版日期 | 2024-04-15 |
| 卷号 | 921页码:13 |
| 关键词 | Renal function Polycyclic aromatic hydrocarbons Metals Mixture exposure Biomarkers Meet-in-the-middle |
| ISSN号 | 0048-9697 |
| DOI | 10.1016/j.scitotenv.2024.170975 |
| 英文摘要 | Studies on the dose effects of kidney impairment and metabolomes in co-exposure to polycyclic aromatic hydrocarbons (PAHs) and metals are limited. We aimed to identify overall associations and metabolic perturbations in 130 participants (53 petrochemical workers and 77 controls) exposed to a PAHs-metals mixture in Southern China. The urinary 7 hydroxylated PAHs and 15 metal(loid)s were determined, and serum creatinine, beta -2 microglobulin, and estimated glomerular filtration rate were health outcomes. The liquid chromatographymass spectrometry-based method was applied to serum metabolomics. Generalized weighted quantile sum (gWQS) regressions were used to estimate the overall dose -response relationships, and pathway analysis, "meetin -the -middle" approach, and mediation effect analyses were conducted to identify potential metabolites and biological mechanisms linking exposure with nephrotoxic effects. Our results indicated that renal function reduction was associated with a PAHs-metals mixture in a dose -dependent manner, and 1-hydroxynaphthalene and copper were the most predominant contributors among the two families of pollutants. Furthermore, the metabolic disruptions associated with the early onset of kidney impairment induced by the combination of PAHs and metals encompassed pathways such as phenylalanine-tyrosine-tryptophan biosynthesis, phenylalanine metabolism, and alpha-linolenic acid metabolism. In addition, the specifically identified metabolites demonstrated excellent potential as bridging biomarkers connecting the reduction in renal function with the mixture of PAHs and metals. These findings shed light on understanding the overall associations and metabolic mechanism of nephrotoxic effects of co -exposure to PAHs and metals. |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001196570200001 |
| 源URL | [http://ir.gig.ac.cn/handle/344008/77224]  |
| 专题 | 中国科学院广州地球化学研究所 |
| 通讯作者 | Luo, Weikeng; Yan, Xiao |
| 作者单位 | 1.Guizhou Med Univ, Sch Publ Hlth, Key Lab Environm Pollut Monitoring & Dis Control, Minist Educ, Guiyang 550025, Peoples R China 2.Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Hong Kong Macao Joint Lab Environm Pollu, Hong Kong 510640, Peoples R China 3.Minist Ecol & Environm, South China Inst Environm Sci, Res Ctr Emerging Contaminants, State Environm Protect Key Lab Environm Pollut Hlt, Guangzhou 510655, Peoples R China 4.China Med Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Shenyang 110122, Peoples R China 5.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangdong Key Lab Environm Resources Utilizat & Pr, Guangzhou 510640, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liao, Qilong,Huang, Lulu,Cai, Fengshan,et al. Metabolomics perspectives into the co-exposure effect of polycyclic aromatic hydrocarbons and metals on renal function: A meet-in-the-middle approach[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2024,921:13. |
| APA | Liao, Qilong.,Huang, Lulu.,Cai, Fengshan.,Luo, Weikeng.,Li, Min.,...&Zheng, Jing.(2024).Metabolomics perspectives into the co-exposure effect of polycyclic aromatic hydrocarbons and metals on renal function: A meet-in-the-middle approach.SCIENCE OF THE TOTAL ENVIRONMENT,921,13. |
| MLA | Liao, Qilong,et al."Metabolomics perspectives into the co-exposure effect of polycyclic aromatic hydrocarbons and metals on renal function: A meet-in-the-middle approach".SCIENCE OF THE TOTAL ENVIRONMENT 921(2024):13. |
入库方式： OAI收割
来源：广州地球化学研究所
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