In vitro hepatic metabolism of polychlorinated biphenyls with different chlorine-substituted structures in rats and humans: Kinetics, metabolism, and potential nuclear receptor affinities
文献类型：期刊论文
| 作者 | Huang, Chenchen1,4,5; Hu, Keqi1,3,5; Zeng, Yanhong1,3,5; Jiang, Yiye1,2,5; Tian, Yankuan1,3,5; Luo, Xiaojun1,3,5 ; Mai, Bixian1,5
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| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
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| 出版日期 | 2023-03-15 |
| 卷号 | 864页码:10 |
| 关键词 | Hepatic metabolism Polychlorinated biphenyls Human Rat Nuclear receptor affinities |
| ISSN号 | 0048-9697 |
| DOI | 10.1016/j.scitotenv.2022.161043 |
| 英文摘要 | In this study, the biotransformation behavior and potential nuclear receptor affinities of polychlorinated biphenyls (PCBs) with different chlorine-substituted structures (PCB 77/110/136/174) were explored using human and rat liver microsomes (HLM and RLM). The rate constants (kobs) of PCBs showed the variations in the order patterns for the HLM (PCB 136 > PCB 110 > PCB 174 > PCB 77) and RLM (PCB 110 > PCB 136 > PCB 174 > PCB 77). However, studied PCBs showed similar metabolite profiles and enantioselective of PCBs between HLM and RLM. The Mono-OH -PCBs were the major metabolites of PCB 77/174, whereas mono -OH-and di-OH-PCBs were the major metabolites of PCB 110/136 for the HLM and RLM, indicating that OH-PCBs could be further oxidized. Enantiomeric enrichment of (-)-PCB 136 and (+)-PCB 174 was observed in microsomal metabolism. Moreover, the inflection point of the enan-tiomer fraction for PCB 136 metabolized by the HLM suggests a competitive metabolism between individual atropisomers. Furthermore, molecular docking results demonstrated the relatively high affinity between PCBs (or OH-PCBs) and certain nuclear receptors, indicating that abnormal metabolic enzyme expression and endocrine disruption occur in PCB-exposed humans. |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:000921555300001 |
| 源URL | [http://ir.gig.ac.cn/handle/344008/72507]  |
| 专题 | 有机地球化学国家重点实验室 |
| 通讯作者 | Zeng, Yanhong |
| 作者单位 | 1.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Hong Kong MaCao Joint Lab Environm Pollu, Hong Kong 510640, Guangdong, Peoples R China 4.China Univ Min & Technol, Sch Environm Sci & Spatial Informat, Xuzhou 221116, Jiangsu, Peoples R China 5.Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Key Lab Environm Protect & Resources Uti, Guangzhou 510640, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Chenchen,Hu, Keqi,Zeng, Yanhong,et al. In vitro hepatic metabolism of polychlorinated biphenyls with different chlorine-substituted structures in rats and humans: Kinetics, metabolism, and potential nuclear receptor affinities[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2023,864:10. |
| APA | Huang, Chenchen.,Hu, Keqi.,Zeng, Yanhong.,Jiang, Yiye.,Tian, Yankuan.,...&Mai, Bixian.(2023).In vitro hepatic metabolism of polychlorinated biphenyls with different chlorine-substituted structures in rats and humans: Kinetics, metabolism, and potential nuclear receptor affinities.SCIENCE OF THE TOTAL ENVIRONMENT,864,10. |
| MLA | Huang, Chenchen,et al."In vitro hepatic metabolism of polychlorinated biphenyls with different chlorine-substituted structures in rats and humans: Kinetics, metabolism, and potential nuclear receptor affinities".SCIENCE OF THE TOTAL ENVIRONMENT 864(2023):10. |
入库方式： OAI收割
来源：广州地球化学研究所
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