Calculated cancer risks for polycyclic aromatic hydrocarbon mixtures in mainstream smoke of cigarettes sold in China
文献类型：期刊论文
| 作者 | Gao, Bo1,5; Ma, Shexia5; Zhao, Wei5; Tian, Mi4; Huang, Yumei3; Chen, Laiguo5; Zhang, Zhou2; Zhong, Zhiqiang5 |
| 刊名 | REGULATORY TOXICOLOGY AND PHARMACOLOGY
 |
| 出版日期 | 2023-08-01 |
| 卷号 | 142页码:8 |
| 关键词 | Cigarette Mainstream smoke Polycyclic aromatic hydrocarbons Risk assessment China |
| ISSN号 | 0273-2300 |
| DOI | 10.1016/j.yrtph.2023.105427 |
| 英文摘要 | China is the world's largest consumer of cigarettes. However, the potential cancer risk posed by polycyclic aromatic hydrocarbons (PAHs) in mainstream cigarette smoke, especially species other than benzo[a]pyrene (BaP) remains unclear. In this study, we collected yield data on multiple PAH species from a variety of cigarettes in the China market and calculated their smoking-related incremental lifetime cancer risk (ILCR) values. The computed ILCRs of the total PAHs (ILCR & sigma;PAHs) for & GE;95% of the brands were one order of magnitude higher than the acceptable level. ILCRBaP accounted for only 5.0%-37.7% of ILCR & sigma;PAHs among brands, indicating that using single analyte BaP to represent & sigma;PAHs would significantly underestimate ILCR & sigma;PAHs. No clear trend of changes in ILCR & sigma;PAHs was found for Chinese cigarettes over multiple years, suggesting that smoking cessation is still the best option to minimize the cancer risk of PAHs. The comparison study showed that rarely reported PAHs from Chinese cigarettes can contribute over half of ILCR & sigma;PAHs for several American cigarettes, highlighting the imperativeness to improve the diversity of analytes for Chinese cigarettes. Adults would need to inhale the airborne PAHs with a BaP equivalent concentration of at least 53.1 ng/m3 to reach the ILCR value comparable to that obtained from smoking. |
| WOS研究方向 | Legal Medicine ; Pharmacology & Pharmacy ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:001033428100001 |
| 源URL | [http://ir.gig.ac.cn/handle/344008/74484]  |
| 专题 | 有机地球化学国家重点实验室 |
| 通讯作者 | Gao, Bo; Tian, Mi |
| 作者单位 | 1.Minist Ecol & Environm, South China Inst Environm Sci, Guangzhou 510535, Peoples R China 2.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Peoples R China 3.South China Agr Univ, Univ Joint Lab Guangdong Prov, Coll Marine Sci, Hong Kong & Macao Reg Marine Bioresource Conservat, Guangzhou 510642, Peoples R China 4.Chongqing Univ, Coll Environm & Ecol, Chongqing 400045, Peoples R China 5.Minist Ecol & Environm, South China Inst Environm Sci, Guangdong Prov Key Lab Water & Air Pollut Control, Guangzhou 510535, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Bo,Ma, Shexia,Zhao, Wei,et al. Calculated cancer risks for polycyclic aromatic hydrocarbon mixtures in mainstream smoke of cigarettes sold in China[J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY,2023,142:8. |
| APA | Gao, Bo.,Ma, Shexia.,Zhao, Wei.,Tian, Mi.,Huang, Yumei.,...&Zhong, Zhiqiang.(2023).Calculated cancer risks for polycyclic aromatic hydrocarbon mixtures in mainstream smoke of cigarettes sold in China.REGULATORY TOXICOLOGY AND PHARMACOLOGY,142,8. |
| MLA | Gao, Bo,et al."Calculated cancer risks for polycyclic aromatic hydrocarbon mixtures in mainstream smoke of cigarettes sold in China".REGULATORY TOXICOLOGY AND PHARMACOLOGY 142(2023):8. |
入库方式： OAI收割
来源：广州地球化学研究所
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