Bioaccumulation, tissue distributions, and maternal transfer of perfluoroalkyl carboxylates (PFCAs) in laying hens
文献类型：期刊论文
| 作者 | Feng, Qun-Jie2,4; Luo, Xiao-Jun1,3,4; Ye, Mei-Xia2,4; Hu, Ke-Qi1,3,4; Zeng, Yan-Hong1,3,4; Mai, Bi-Xian1,3,4 |
| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
 |
| 出版日期 | 2023-12-20 |
| 卷号 | 905页码:9 |
| 关键词 | Perfluoroalkyl carboxylates Laying hens Toxicokinetic Maternal transfer |
| ISSN号 | 0048-9697 |
| DOI | 10.1016/j.scitotenv.2023.167008 |
| 英文摘要 | Laying hens were exposed to feeds spiked with a series of perfluoroalkyl carboxylates (PFCAs) ranging from perfluorobutanoic acid (C4) to perfluorooctadecanoic acid (C18) to investigate their bioaccumulation, tissue distribution, and maternal transfer. We found that PFCAs with longer carbon chains (>8) were more efficiently absorbed in the gastrointestinal tract than those with shorter chains (<= 8), and that the rate of depuration varied inversely with the carbon chain length in a U-shaped pattern. Moreover, bioaccumulation potential increased with increasing carbon-chain length, except for C4. Distinct affinities were observed for specific carbon-chain PFCAs across various tissues, evident from their differential accumulation during both uptake and depuration phases. Specifically, C9 showed a higher affinity for serum and liver, C12 was more prevalent in yolk, C14 was notably abundant in the brain, and C18 was predominant in other tissues. Furthermore, the egg-maternal ratio (EMR) increased with increasing carbon-chain length from C7 to C11 and reached a plateau phase for C12 to C18. Our study also confirmed the key role of phospholipids in the tissue distribution and maternal transfer of long-chain PFCAs. This study sheds light on the interaction between PFCAs and biological tissues and reveals the toxicokinetic factors that influence the bioaccumulation of PFCAs. Further research is needed to identify the specific proteins or components that mediate the tissue-specific affinity for different carbon-chain lengths of PFCAs. |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001082079100001 |
| 源URL | [http://ir.gig.ac.cn/handle/344008/74963]  |
| 专题 | 有机地球化学国家重点实验室 |
| 通讯作者 | Luo, Xiao-Jun |
| 作者单位 | 1.Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Hong Kong Macao Joint Lab Environm Pollu, Hong Kong 510640, Guangdong, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.CAS Ctr Excellence Deep Earth Sci, Guangzhou 510640, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangdong Key Lab Environm Resources Utilizat & Pr, Guangzhou 510640, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Qun-Jie,Luo, Xiao-Jun,Ye, Mei-Xia,et al. Bioaccumulation, tissue distributions, and maternal transfer of perfluoroalkyl carboxylates (PFCAs) in laying hens[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2023,905:9. |
| APA | Feng, Qun-Jie,Luo, Xiao-Jun,Ye, Mei-Xia,Hu, Ke-Qi,Zeng, Yan-Hong,&Mai, Bi-Xian.(2023).Bioaccumulation, tissue distributions, and maternal transfer of perfluoroalkyl carboxylates (PFCAs) in laying hens.SCIENCE OF THE TOTAL ENVIRONMENT,905,9. |
| MLA | Feng, Qun-Jie,et al."Bioaccumulation, tissue distributions, and maternal transfer of perfluoroalkyl carboxylates (PFCAs) in laying hens".SCIENCE OF THE TOTAL ENVIRONMENT 905(2023):9. |
入库方式： OAI收割
来源：广州地球化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。