Methods for the characterisation of dermal uptake: Progress and perspectives for organophosphate esters
文献类型：期刊论文
| 作者 | Wang, Zhexi3; Geng, Shuxiang3; Zhang, Jiayi3; Yang, Hengkang3; Shi, Shiyu3; Zhao, Leicheng3; Luo, Xiaojun1,2 ; Cao, Zhiguo3
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| 刊名 | ENVIRONMENT INTERNATIONAL
 |
| 出版日期 | 2024 |
| 卷号 | 183页码:13 |
| 关键词 | Dermal uptake Exposure assessment model Permeability coefficient ( K p ) Organophosphate esters |
| ISSN号 | 0160-4120 |
| DOI | 10.1016/j.envint.2023.108400 |
| 英文摘要 | Organophosphate esters (OPEs) are a group of pollutants that are widely detected in the environment at high concentrations. They can adversely affect human health through multiple routes of exposure, including dermal uptake. Although attention has been paid to achieving an accurate and complete quantification of the dermal uptake of OPEs, existing evaluation methods and parameters have obvious weaknesses. This study reviewed two main categories of methodologies, namely the relative absorption (RA) model and the permeability coefficient (PC) model, which are widely used to assess the dermal uptake of OPEs. Although the PC model is more accurate and is increasingly used, the most important parameter in this model, the permeability coefficient (Kp), has been poorly characterised for OPEs, resulting in considerable errors in the estimation of the dermal uptake of OPEs. Thus, the detailed in vitro methods for the determination of Kp are summarised and sorted. Furthermore, the commonly used skin membranes are identified and the factors affecting Kp and corresponding mechanisms are discussed. In addition, the experimental conditions, conclusions, and available data on Kp values of the OPEs are thoroughly summarised. Finally, the corresponding knowledge gaps are proposed, and a more accurate and sophisticated experimental system and unknown Kp values for OPEs are suggested. |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001145112100001 |
| 源URL | [http://ir.gig.ac.cn/handle/344008/76167]  |
| 专题 | 有机地球化学国家重点实验室 |
| 通讯作者 | Luo, Xiaojun; Cao, Zhiguo |
| 作者单位 | 1.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Peoples R China 2.Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Key Lab Environm Resources Utilizat & Pr, Guangzhou 510640, Peoples R China 3.Henan Normal Univ, Sch Environm, Key Lab Yellow River & Huai River Water Environm &, Minist Educ, Xinxiang 453007, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zhexi,Geng, Shuxiang,Zhang, Jiayi,et al. Methods for the characterisation of dermal uptake: Progress and perspectives for organophosphate esters[J]. ENVIRONMENT INTERNATIONAL,2024,183:13. |
| APA | Wang, Zhexi.,Geng, Shuxiang.,Zhang, Jiayi.,Yang, Hengkang.,Shi, Shiyu.,...&Cao, Zhiguo.(2024).Methods for the characterisation of dermal uptake: Progress and perspectives for organophosphate esters.ENVIRONMENT INTERNATIONAL,183,13. |
| MLA | Wang, Zhexi,et al."Methods for the characterisation of dermal uptake: Progress and perspectives for organophosphate esters".ENVIRONMENT INTERNATIONAL 183(2024):13. |
入库方式： OAI收割
来源：广州地球化学研究所
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