Trace analysis of 47 psychotropic medications in environmental samples by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS)
文献类型：期刊论文
| 作者 | Wang, Anguo2,3,4; Zhang, Jinna3; Hu, Lixin1,5; Yu, Zhiqiang4; Lai, Sihua3; Liu, Yousheng1,5; Mai, Zhiyuan3; Xu, Meiying3 |
| 刊名 | JOURNAL OF CHROMATOGRAPHY A
 |
| 出版日期 | 2024-01-25 |
| 卷号 | 1715页码:14 |
| 关键词 | Psychotropic medications Water sample extraction Solid sample extraction UPLC-MS/MS Environmental monitoring |
| ISSN号 | 0021-9673 |
| DOI | 10.1016/j.chroma.2023.464627 |
| 英文摘要 | Psychotropic medications are one of the most prescribed pharmaceuticals in the world. Given their frequent detection and ecotoxicity to the no-target organism, the emission of these medications into environments has gradually draw attention. The study developed a sensitive and reliable analytic method to simultaneously investigate 47 psychotropic medications in four matrices: wastewater, surface water, activated sludge, and sediment by ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS). These 47 target analytes include 24 antidepressants, 17 antianxiety drugs, 5 anticonvulsants, and 1 relevant hormone. Solid phase extraction (SPE) was employed to extract analytes from water-phase samples. Ultrasonic Solvent Extraction method with Enhanced Matrix Removal clean-up (USE-EMR) was utilized to extract target compounds from solid-phase samples, which requires more straightforward and convenient procedures than previous methods. The extraction recoveries of all analytes ranged from 80 % to 120 % in these four sample matrices. In this study, The limit of quantitation for 47 psychotropic medications were 0.15 ng/L (estazolam) to 2.27 ng/L (lorazepam), 0.08 ng/L (desvenlafaxine) to 2 ng/L (mianserin), 0.22 ng/g (dry weight, dw) (nordiazepam) to 3.65 ng/g (dw) (lorazepam), and 0.07 ng/g (dw) (carbamazepine) to 2.85 ng/g (lorazepam), in wastewater, surface water, sludge, and sediment, respectively. In addition, the developed method was employed to analyse actual samples in two wastewater treatment plants and their receiving rivers. Carbamazepine, escitalopram, clozapine, desvenlafaxine, diazepam, lamotrigine, sertraline, temazepam, and venlafaxine were nearly ubiquitous in all matrices. Moreover, this study indicated that the inadequate removal efficiencies of psychotropic medications in wastewater treatment plants (WWTPs) had resulted in a persistent discharge of these contaminants from human sources into environments. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001154201100001 |
| 源URL | [http://ir.gig.ac.cn/handle/344008/76194]  |
| 专题 | 有机地球化学国家重点实验室 |
| 通讯作者 | Xu, Meiying |
| 作者单位 | 1.South China Normal Univ, MOE Key Lab Environm Theoret Chem, Guangzhou 510006, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Guangdong Acad Sci, Guangdong Environm Protect Key Lab Microbiol & Eco, Guangdong Prov Key Lab Microbial Culture Collect &, Inst Microbiol,State Key Lab Appl Microbiol Southe, Guangzhou 510070, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Peoples R China 5.South China Normal Univ, SCNU Environm Res Inst, Guangdong Prov Key Lab Chem Pollut & Environm Safe, Guangzhou 510006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Anguo,Zhang, Jinna,Hu, Lixin,et al. Trace analysis of 47 psychotropic medications in environmental samples by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS)[J]. JOURNAL OF CHROMATOGRAPHY A,2024,1715:14. |
| APA | Wang, Anguo.,Zhang, Jinna.,Hu, Lixin.,Yu, Zhiqiang.,Lai, Sihua.,...&Xu, Meiying.(2024).Trace analysis of 47 psychotropic medications in environmental samples by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS).JOURNAL OF CHROMATOGRAPHY A,1715,14. |
| MLA | Wang, Anguo,et al."Trace analysis of 47 psychotropic medications in environmental samples by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS)".JOURNAL OF CHROMATOGRAPHY A 1715(2024):14. |
入库方式： OAI收割
来源：广州地球化学研究所
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