PFASs in Cerebrospinal Fluids and Blood-CSF Barrier Permeability in Patients with Cognitive Impairment
文献类型：期刊论文
| 作者 | Hong, Xiaowen1,9,10; Tao, Lin5,6,7,8; Guo, Liyan5,6,7,8; Luo, Lin5,6,7,8; Lv, Jia5,6,7,8; Li, Ruonan5,6,7,8; Hu, Jiayue4; Gao, Chang5,6,7,8; Wang, Hua5,6,7,8; Xu, De-Xiang5,6,7,8 |
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2024-02-22 |
| 卷号 | 58期号:11页码:5129-5138 |
| 关键词 | PFASs PFOS cognitive impairment CSF blood-CSF barrier |
| ISSN号 | 0013-936X |
| DOI | 10.1021/acs.est.3c10511 |
| 英文摘要 | Attention has been drawn to the associations between PFASs and human cognitive decline. However, knowledge on the occurrence and permeability of PFASs in the brains of patients with cognitive impairment has not been reported. Here, we determined 30 PFASs in paired sera and cerebrospinal fluids (CSFs) from patients with cognitive impairment (n = 41) and controls without cognitive decline (n = 18). We revealed similar serum PFAS levels but different CSF PFAS levels, with lower CSF PFOA (median: 0.125 vs 0.303 ng/mL, p < 0.05), yet higher CSF PFOS (0.100 vs 0.052 ng/mL, p < 0.05) in patients than in controls. Blood-brain transfer rates also showed lower R-CSF/Serum values for PFOA and higher R-CSF/Serum values for PFOS in patients, implying potential heterogeneous associations with cognitive function. The R (CSF/Serum) values for C4-C14 perfluoroalkyl carboxylates exhibited a U-shape trend with increasing chain length. Logistic regression analyses demonstrated that CSF PFOS levels were linked to the heightened risk of cognitive impairment [odds ratio: 3.22 (1.18-11.8)] but not for serum PFOS. Toxicity inference results based on the Comparative Toxicogenomics Database suggested that PFOS in CSF may have a greater potential to impair human cognition than other PFASs. Our results contribute to a better understanding of brain PFAS exposure and its potential impact on cognitive function. [GRAPHICS] |
| WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001174409600001 |
| 源URL | [http://ir.gig.ac.cn/handle/344008/77291]  |
| 专题 | 有机地球化学国家重点实验室 |
| 通讯作者 | Tang, Qiqiang; Huang, Yichao |
| 作者单位 | 1.Anhui Med Univ, Anhui Prov Hosp, Dept Neurol, Hefei 230032, Anhui, Peoples R China 2.Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Key Lab Environm Protect & Resources Uti, Guangzhou 510640, Peoples R China 3.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Peoples R China 4.Anhui Med Univ, Sch Publ Hlth, Dept Hyg Inspect & Quarantine, Hefei 230032, Peoples R China 5.Anhui Med Univ, MOE Key Lab Populat Hlth Life Cycle, Hefei 230032, Peoples R China 6.Anhui Med Univ, Anhui Higher Educ Inst, Key Lab Environm Toxicol, Hefei 230032, Peoples R China 7.Anhui Med Univ, Ctr Big Data & Populat Hlth IHM, Hefei 230032, Peoples R China 8.Anhui Med Univ, Sch Publ Hlth, Dept Toxicol, Hefei 230032, Peoples R China 9.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Neurol, Div Life Sci & Med, Hefei 230032, Anhui, Peoples R China 10.Anhui Med Univ, Sch Clin Med 5, Hefei 230032, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hong, Xiaowen,Tao, Lin,Guo, Liyan,et al. PFASs in Cerebrospinal Fluids and Blood-CSF Barrier Permeability in Patients with Cognitive Impairment[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2024,58(11):5129-5138. |
| APA | Hong, Xiaowen.,Tao, Lin.,Guo, Liyan.,Luo, Lin.,Lv, Jia.,...&Huang, Yichao.(2024).PFASs in Cerebrospinal Fluids and Blood-CSF Barrier Permeability in Patients with Cognitive Impairment.ENVIRONMENTAL SCIENCE & TECHNOLOGY,58(11),5129-5138. |
| MLA | Hong, Xiaowen,et al."PFASs in Cerebrospinal Fluids and Blood-CSF Barrier Permeability in Patients with Cognitive Impairment".ENVIRONMENTAL SCIENCE & TECHNOLOGY 58.11(2024):5129-5138. |
入库方式： OAI收割
来源：广州地球化学研究所
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