Toward an Understanding of Uric Acid Particle Dissolution: Surface and Bulk-Driven Water Activity
文献类型：期刊论文
| 作者 | Rastogi, Dewansh1,3; Gohil, Kanishk1; Malek, Kotiba A.1; Peng, Chao2; Tang, Mingjin2 ; Asa-Awuku, Akua1
|
| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY A
 |
| 出版日期 | 2024-07-23 |
| 卷号 | 128期号:30页码:6254-6263 |
| ISSN号 | 1089-5639 |
| DOI | 10.1021/acs.jpca.4c02388 |
| 英文摘要 | Uric acid particles contribute to kidney stones, and natural processes for the elimination of stones depend on solute-solvent interactions. The process of uric acid dissolution has previously been understood via the lens of solubility; however, for pure and mixed salt solutions, these approaches do not provide a comprehensive picture of nanoscale particle solution thermodynamics. Unlike solubility measurements, water activity measurements provide us with information about the chemical potential responsible for the migration of water molecules driving the dissolution of particles. In this work, we used in situ experimental tools to estimate water activity values for pure uric acid aqueous droplets at different stages of droplet growth. The process of cloud formation, i.e., water condensation on a solute particle resulting in aqueous droplet formation, was leveraged to compare the water affinity for nanosized uric acid particles with a well-studied inorganic salt, sodium chloride. Specifically, we investigated microscopic uric acid particles (nanoparticles <300 nm, amorphous and super micron particles >5 mu m, crystalline) and the mechanism of water uptake. The growth of droplet volume (Growth Factor, GF) for uric acid particles is experimentally observed for supermicrometer crystalline particles (>1 mu m) at subsaturated humidity conditions (<100% RH). In addition, the water activity of submicrometer-size uric acid particles is estimated under subsaturated and supersaturated humidity conditions. These measurements provide us with information about the volume growth of droplets as water condenses in particles exposed to different humidity conditions. Our observations under subsaturated humidity conditions show that the uric acid particles have limited volume growth (<1% change per volume and <10% change per volume for crystalline and amorphous measurement, respectively). From the experimental data, the affinity of uric acid solute with water as a solvent is quantified in terms of water activity. |
| WOS研究方向 | Chemistry ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001275508800001 |
| 源URL | [http://ir.gig.ac.cn/handle/344008/78165]  |
| 专题 | 有机地球化学国家重点实验室 |
| 通讯作者 | Asa-Awuku, Akua |
| 作者单位 | 1.Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA 2.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Peoples R China 3.Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA |
| 推荐引用方式 GB/T 7714 | Rastogi, Dewansh,Gohil, Kanishk,Malek, Kotiba A.,et al. Toward an Understanding of Uric Acid Particle Dissolution: Surface and Bulk-Driven Water Activity[J]. JOURNAL OF PHYSICAL CHEMISTRY A,2024,128(30):6254-6263. |
| APA | Rastogi, Dewansh,Gohil, Kanishk,Malek, Kotiba A.,Peng, Chao,Tang, Mingjin,&Asa-Awuku, Akua.(2024).Toward an Understanding of Uric Acid Particle Dissolution: Surface and Bulk-Driven Water Activity.JOURNAL OF PHYSICAL CHEMISTRY A,128(30),6254-6263. |
| MLA | Rastogi, Dewansh,et al."Toward an Understanding of Uric Acid Particle Dissolution: Surface and Bulk-Driven Water Activity".JOURNAL OF PHYSICAL CHEMISTRY A 128.30(2024):6254-6263. |
入库方式： OAI收割
来源：广州地球化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。