Phthalate metabolites in breast milk from mothers in Southern China: Occurrence, temporal trends, daily intake, and risk assessment
文献类型：期刊论文
| 作者 | Liu, Yangyang4; Xiao, Minhua3; Huang, Kaiqin4; Cui, Juntao2; Liu, Hongli4; Yu, Yingxin4; Ma, Shengtao1,4; Liu, Xihong3; Lin, Meiqing4 |
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2024-02-15 |
| 卷号 | 464页码:8 |
| 关键词 | Phthalate metabolites Lactating women Breast milk Temporal trend Risk assessment |
| ISSN号 | 0304-3894 |
| DOI | 10.1016/j.jhazmat.2023.132895 |
| 英文摘要 | The extensive production and use of phthalates means that these compounds are now ubiquitous in the environment and various biota, which raises concerns about potential harmful health effects. In this study, phthalate metabolites (mPAEs) were measured in breast milk (n = 100) collected from mothers of southern China between 2014 - 2022. Of the nine target mPAEs, five were detected in all of the samples, including mono-methyl phthalate (MMP), mono-ethyl phthalate (MEP), mono-isobutyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), and mono-(2-ethylhexyl) phthalate (MEHP). The total levels of mPAEs in breast milk ranged from 4.76 to 51.6 ng/mL, with MiBP and MnBP being the predominant isomers (MiBP + MnBP > 48.3%). Increasing trends were observed in MMP (5.7%/year) and MEHP (7.1%/year) levels during the study period, while a decreasing trend were observed in MiBP (-6.6%/year); no clear temporal trends were found for the other metabolites and total mPAE levels. The results indicate that exposure to phthalates is still prevalent in southern China. Breastfeeding was found to contribute to estimated daily phthalate intakes of 0.383-6.95 mu g/kg-bw/day, gesting insignificant health risks to infants based on dietary exposure. However, the increasing exposure to and MEHP calls for more research into the possible sources and potential risks. |
| WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001115599400001 |
| 源URL | [http://ir.gig.ac.cn/handle/344008/79076]  |
| 专题 | 有机地球化学国家重点实验室 |
| 通讯作者 | Liu, Xihong; Lin, Meiqing |
| 作者单位 | 1.Guangzhou Med Univ, Sch Publ Hlth, Guangzhou 511436, Peoples R China 2.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Peoples R China 3.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Dept Clin Nutr, Guangzhou 510623, Guangdong, Peoples R China 4.Guangdong Univ Technol, Sch Environm Sci & Engn, Guangdong Hong Kong Macao Joint Lab Contaminants E, Hong Kong 510006, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yangyang,Xiao, Minhua,Huang, Kaiqin,et al. Phthalate metabolites in breast milk from mothers in Southern China: Occurrence, temporal trends, daily intake, and risk assessment[J]. JOURNAL OF HAZARDOUS MATERIALS,2024,464:8. |
| APA | Liu, Yangyang.,Xiao, Minhua.,Huang, Kaiqin.,Cui, Juntao.,Liu, Hongli.,...&Lin, Meiqing.(2024).Phthalate metabolites in breast milk from mothers in Southern China: Occurrence, temporal trends, daily intake, and risk assessment.JOURNAL OF HAZARDOUS MATERIALS,464,8. |
| MLA | Liu, Yangyang,et al."Phthalate metabolites in breast milk from mothers in Southern China: Occurrence, temporal trends, daily intake, and risk assessment".JOURNAL OF HAZARDOUS MATERIALS 464(2024):8. |
入库方式： OAI收割
来源：广州地球化学研究所
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