Antifungal Pseuboyenes A-J, Bergamotene-Derived Sesquiterpenoids from a Cold-Seep-Derived Pseudallescheria boydii
文献类型：期刊论文
| 作者 | Ying, Zhen1,2,3; Li, Xiao-Ming2,3; Yang, Sui-Qun2,3; Li, Hong-Lei2,3 ; Li, Xin2,3; Wang, Bin-Gui1,2,3,4; Meng, Ling-Hong1,2,3,4
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2024-05-03 |
| 卷号 | 87期号:5页码:1347-1357 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.3c01175 |
| 通讯作者 | Meng, Ling-Hong(menglh@ms.qdio.ac.cn) |
| 英文摘要 | A chemical investigation of a cold-seep-sediment-derived fungus, Pseudallescheria boydii CS-793, resulted in characterization of 10 novel bergamotene-derived sesquiterpenoids, pseuboyenes A-J (1-10). Their structures were elucidated by spectroscopic and X-ray crystallographic analyses as well as using the modified Mosher's method. Compound 1 represents the first example of a beta-bergamotene containing a 6-oxobicyclo[3.2.1]octane nucleus adducted with a methyl lactate unit, while 8-10 involve a skeletal rearrangement from bergamotene. Compounds 2-5 showed significant antifungal activities against Colletotrichum gloeosporioides Penz. and Fusarium oxysporum with MICs ranging from 0.5 to 8 mu g/mL. Compound 4 exhibited an in vitro anti-F. proliferatum effect with an EC50 value of 1.0 mu g/mL. |
| WOS关键词 | EMERGING FUNGAL ; CONFIGURATION ; THREATS |
| 资助项目 | National Natural Science Foundation of China[42176115] ; National Natural Science Foundation of China[U2006203] ; National Natural Science Foundation of China[41976090] ; National Natural Science Foundation of China[BK20201211] ; National Natural Science Foundation of China[KEXUE2020GZ02] ; Natural Science Foundation of Jiangsu Province ; National Major Science and Technology Infrastructure from the Chinese Academy of Sciences |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001225398300001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/185748]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Meng, Ling-Hong |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Megasci, CAS, Qingdao 266071, Peoples R China 4.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ying, Zhen,Li, Xiao-Ming,Yang, Sui-Qun,et al. Antifungal Pseuboyenes A-J, Bergamotene-Derived Sesquiterpenoids from a Cold-Seep-Derived Pseudallescheria boydii[J]. JOURNAL OF NATURAL PRODUCTS,2024,87(5):1347-1357. |
| APA | Ying, Zhen.,Li, Xiao-Ming.,Yang, Sui-Qun.,Li, Hong-Lei.,Li, Xin.,...&Meng, Ling-Hong.(2024).Antifungal Pseuboyenes A-J, Bergamotene-Derived Sesquiterpenoids from a Cold-Seep-Derived Pseudallescheria boydii.JOURNAL OF NATURAL PRODUCTS,87(5),1347-1357. |
| MLA | Ying, Zhen,et al."Antifungal Pseuboyenes A-J, Bergamotene-Derived Sesquiterpenoids from a Cold-Seep-Derived Pseudallescheria boydii".JOURNAL OF NATURAL PRODUCTS 87.5(2024):1347-1357. |
入库方式： OAI收割
来源：海洋研究所
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