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The potential mechanisms for isoliquiritigenin on the growth and immune regulation of Penaeus vannamei revealed by transcriptomic and metabolomic

文献类型：期刊论文

作者Yang, Xuanyi2,3,4; Liu, Mei5; Liang, Qinlang1; Jiang, Keyong2,3; Wang, Baojie2,3; Wang, Lei2,3,4
刊名AQUACULTURE
出版日期2024-08-30
卷号589页码:15
关键词Isoliquiritigenin Immunity Growth Penaeus vanname Transcriptomic and metabolomic
ISSN号0044-8486
DOI10.1016/j.aquaculture.2024.740945
通讯作者Wang, Baojie(wangbaojie@qdio.ac.cn) ; Wang, Lei(leiwang@qdio.ac.cn)
英文摘要The resistance of Penaeus vannamei to disease invasion is crucial for the development of the shrimp industry. It is unknown whether isoliquiritigenin (ISL) can serve as an efficient immunostimulant for P. vannamei. The growth, antioxidant, apoptosis, and immunity were used to assess the feasibility of ISL as an immunostimulant. Transcriptomics and metabolomics were used to investigate the mechanism of immune stimulation by ISL. It was found that ISL had no effect on the survival rate of P. vannamei. Dietary ISL can enhance growth and the expressions of antioxidant, anti-stress, and immune (excluding antimicrobial peptides) related genes. Transcriptome analysis revealed that numerous up-regulated DEGs (differentially expressed genes) were involved in immune regulation. The significantly enriched functions and pathways of DEGs were commonly involved in metabolism and immunity. The DMs (differential metabolites) and key metabolite nodes were mostly mapped to the regulation of growth, nutrient metabolism, and immune response. In conclusion, dietary ISL can improve the growth, antioxidant capacity, stress resistance, and immunity of P. vannamei. These improvements may be achieved by regulating signaling pathways (Toll-like receptor signaling pathway, glutathione metabolism, signal transduction-related pathways, HIF-1 signaling pathway, PPAR signaling pathway) and altering the abundance of metabolite with antibacterial, anti-inflammatory, and antioxidant capabilities.
WOS关键词PACIFIC WHITE SHRIMP ; LITOPENAEUS-VANNAMEI ; SIGNALING PATHWAY ; ANTIOXIDANT ; FISH ; TOLL ; INHIBITION ; FLAVONOIDS ; RESPONSES ; INNATE
资助项目Fund of the Key R & D Project of Shandong Province[2023TZXD047] ; Shandong Provincial Natural Science Foundation[ZR2023MC096] ; Shandong Provincial Natural Science Foundation[DC6129I202120002]
WOS研究方向Fisheries ; Marine & Freshwater Biology
语种英语
WOS记录号WOS:001231821500001
出版者ELSEVIER
源URL[http://ir.qdio.ac.cn/handle/337002/185867]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Wang, Baojie; Wang, Lei
作者单位1.Tongwei Fishery Technol Co Ltd, Chengdu, Peoples R China
2.Chinese Acad Sci, Qingdao, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Marine Sci Res Inst Shandong Prov, Shandong Key Lab Dis Control Mariculture, Qingdao, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Xuanyi,Liu, Mei,Liang, Qinlang,et al. The potential mechanisms for isoliquiritigenin on the growth and immune regulation of Penaeus vannamei revealed by transcriptomic and metabolomic[J]. AQUACULTURE,2024,589:15.
APA Yang, Xuanyi,Liu, Mei,Liang, Qinlang,Jiang, Keyong,Wang, Baojie,&Wang, Lei.(2024).The potential mechanisms for isoliquiritigenin on the growth and immune regulation of Penaeus vannamei revealed by transcriptomic and metabolomic.AQUACULTURE,589,15.
MLA Yang, Xuanyi,et al."The potential mechanisms for isoliquiritigenin on the growth and immune regulation of Penaeus vannamei revealed by transcriptomic and metabolomic".AQUACULTURE 589(2024):15.

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来源：海洋研究所

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