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Volatile Organic Compounds Produced by a Deep-Sea Bacterium Efficiently Inhibit the Growth of Pseudomonas aeruginosa PAO1

文献类型：期刊论文

作者Hu, Yuanyuan1,2,3,4,5; Liu, Ge2,3,4,5; Sun, Chaomin2,3,4,5,6; Wu, Shimei1
刊名MARINE DRUGS
出版日期2024-05-01
卷号22期号:5页码:17
关键词antibacteria volatile organic compounds Pseudomonas aeruginosa PAO1 cell division biofilm
DOI10.3390/md22050233
通讯作者Sun, Chaomin(sunchaomin@qdio.ac.cn) ; Wu, Shimei(shimeiwu2016@126.com)
英文摘要The deep-sea bacterium Spongiibacter nanhainus CSC3.9 has significant inhibitory effects on agricultural pathogenic fungi and human pathogenic bacteria, especially Pseudomonas aeruginosa, the notorious multidrug-resistant pathogen affecting human public health. We demonstrate that the corresponding antibacterial agents against P. aeruginosa PAO1 are volatile organic compounds (VOCs, namely VOC-3.9). Our findings show that VOC-3.9 leads to the abnormal cell division of P. aeruginosa PAO1 by disordering the expression of several essential division proteins associated with septal peptidoglycan synthesis. VOC-3.9 hinders the biofilm formation process and promotes the biofilm dispersion process of P. aeruginosa PAO1 by affecting its quorum sensing systems. VOC-3.9 also weakens the iron uptake capability of P. aeruginosa PAO1, leading to reduced enzymatic activity associated with key metabolic processes, such as reactive oxygen species (ROS) scavenging. Overall, our study paves the way to developing antimicrobial compounds against drug-resistant bacteria by using volatile organic compounds.
WOS关键词ANTIBACTERIAL
资助项目Science and Technology Innovation Project of Laoshan Laboratory
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001233505900001
出版者MDPI
源URL[http://ir.qdio.ac.cn/handle/337002/185939]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Sun, Chaomin; Wu, Shimei
作者单位1.Qingdao Univ, Coll Life Sci, 308 Ningxia Rd, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Ctr Deep Sea Res, Qingdao 266071, Peoples R China
4.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
6.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 101408, Peoples R China
推荐引用方式
GB/T 7714		 Hu, Yuanyuan,Liu, Ge,Sun, Chaomin,et al. Volatile Organic Compounds Produced by a Deep-Sea Bacterium Efficiently Inhibit the Growth of Pseudomonas aeruginosa PAO1[J]. MARINE DRUGS,2024,22(5):17.
APA Hu, Yuanyuan,Liu, Ge,Sun, Chaomin,&Wu, Shimei.(2024).Volatile Organic Compounds Produced by a Deep-Sea Bacterium Efficiently Inhibit the Growth of Pseudomonas aeruginosa PAO1.MARINE DRUGS,22(5),17.
MLA Hu, Yuanyuan,et al."Volatile Organic Compounds Produced by a Deep-Sea Bacterium Efficiently Inhibit the Growth of Pseudomonas aeruginosa PAO1".MARINE DRUGS 22.5(2024):17.

入库方式： OAI收割

来源：海洋研究所

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