Antibacterial Polyketides from the Deep-Sea Cold-Seep-Derived Fungus Talaromyces sp. CS-258
文献类型：期刊论文
| 作者 | Wu, Zhenger1,3; Li, Xiao-Ming1,3; Yang, Sui-Qun1,3 ; Wang, Bin-Gui1,2,3; Li, Xin1,2,3
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| 刊名 | MARINE DRUGS
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| 出版日期 | 2024-05-01 |
| 卷号 | 22期号:5页码:19 |
| 关键词 | antibacterial activity fungal polyketides cold-seep-derived fungus Talaromyces sp. |
| DOI | 10.3390/md22050204 |
| 通讯作者 | Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Li, Xin(lixin@qdio.ac.cn) |
| 英文摘要 | Thirty-two fungal polyketide derivatives, including eleven new compounds, namely (3R,5 ' R)-5-hydroxytalaroflavone (1), talaroisochromenols A-C (3, 5, and 11), (8R,9R,10aR)-5-hydroxyaltenuene (13), (8R,9R,10aS)-5-hydroxyaltenuene (14), (8R,9S,10aR)-5-hydroxyaltenuene (15), nemanecins D and E (25 and 26), 2,5-dimethyl-8-iodochromone (27), and talarofurolactone A (29), together with one new naturally occurring but previously synthesized metabolite, 6-hydroxy-4-methoxycoumarin (28), were isolated and identified from the deep-sea cold-seep-derived fungus Talaromyces sp. CS-258. Among them, racemic ((+/-)-11) or epimeric (13-15, 25, and 26) mixtures were successfully separated by chiral or gradient elution HPLC. Meanwhile, compound 27 represents a rarely reported naturally occurring iodinated compound. Their planar structures as well as absolute configurations were determined by extensive analysis via NMR, MS, single-crystal X-ray diffraction, Mosher's method, and ECD or NMR calculation (with DP4(+) probability analysis). Possible biosynthetic routes of some isolated compounds, which are related to chromone or isochromone biosynthetic pathways, were put forward. The biological analysis results revealed that compounds 7, 9, 10, 18-22, 24, 30, and 31 showed broad-spectrum antibacterial activities against several human and aquatic pathogens with MIC ranges of 0.5-64 mu g/mL. |
| WOS关键词 | ELECTRONIC CIRCULAR-DICHROISM ; ENDOPHYTIC FUNGUS ; ALTERNARIA SP ; THEORETICAL CALCULATION ; ABSOLUTE-CONFIGURATION ; MYCOTOXINS ALTERNARIOL ; DERIVATIVES ; METABOLITES ; ASSIGNMENT ; ALTENUSIN |
| 资助项目 | National Key R&D Program of China ; National Major Science and Technology Infrastructure from the Chinese Academy of Sciences |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001234880000001 |
| 出版者 | MDPI |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/185945]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Bin-Gui; Li, Xin |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Zhenger,Li, Xiao-Ming,Yang, Sui-Qun,et al. Antibacterial Polyketides from the Deep-Sea Cold-Seep-Derived Fungus Talaromyces sp. CS-258[J]. MARINE DRUGS,2024,22(5):19. |
| APA | Wu, Zhenger,Li, Xiao-Ming,Yang, Sui-Qun,Wang, Bin-Gui,&Li, Xin.(2024).Antibacterial Polyketides from the Deep-Sea Cold-Seep-Derived Fungus Talaromyces sp. CS-258.MARINE DRUGS,22(5),19. |
| MLA | Wu, Zhenger,et al."Antibacterial Polyketides from the Deep-Sea Cold-Seep-Derived Fungus Talaromyces sp. CS-258".MARINE DRUGS 22.5(2024):19. |
入库方式： OAI收割
来源：海洋研究所
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