Exploring the Efficacy of Hydroxybenzoic Acid Derivatives in Mitigating Jellyfish Toxin-Induced Skin Damage: Insights into Protective and Reparative Mechanisms
文献类型：期刊论文
| 作者 | Geng, Hao1,2,3 ; Li, Rongfeng1,3; Teng, Lichao1,2,3; Yu, Chunlin1,3; Wang, Wenjie1,2,3; Gao, Kun1,3; Li, Aoyu1,2,3; Liu, Song1,3; Xing, Ronge1,3; Yu, Huahua1,3
|
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2024-05-01 |
| 卷号 | 22期号:5页码:22 |
| 关键词 | jellyfish protocatechuic acid gentisic acid Nemopilema nomurai nematocyst venom skin necrosis inflammation |
| DOI | 10.3390/md22050205 |
| 通讯作者 | Yu, Huahua(yuhuahua@qdio.ac.cn) |
| 英文摘要 | The escalation of jellyfish stings has drawn attention to severe skin reactions, underscoring the necessity for novel treatments. This investigation assesses the potential of hydroxybenzoic acid derivatives, specifically protocatechuic acid (PCA) and gentisic acid (DHB), for alleviating Nemopilema nomurai Nematocyst Venom (NnNV)-induced injuries. By employing an in vivo mouse model, the study delves into the therapeutic efficacy of these compounds. Through a combination of ELISA and Western blot analyses, histological examinations, and molecular assays, the study scrutinizes the inflammatory response, assesses skin damage and repair mechanisms, and investigates the compounds' ability to counteract venom effects. Our findings indicate that PCA and DHB significantly mitigate inflammation by modulating critical cytokines and pathways, altering collagen ratios through topical application, and enhancing VEGF and bFGF levels. Furthermore, both compounds demonstrate potential in neutralizing NnNV toxicity by inhibiting metalloproteinases and phospholipase-A2, showcasing the viability of small-molecule compounds in managing toxin-induced injuries. |
| WOS关键词 | NOMURAI SCYPHOZOA RHIZOSTOMEAE ; NEMOPILEMA-NOMURAI ; INFLAMMATORY RESPONSE ; CRUDE VENOM ; BLOOMS ; METALLOPROTEINASE ; ENVENOMATION ; MATRIX |
| 资助项目 | National Key R&D Program of China |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001233490300001 |
| 出版者 | MDPI |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/185963]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Yu, Huahua |
| 作者单位 | 1.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Geng, Hao,Li, Rongfeng,Teng, Lichao,et al. Exploring the Efficacy of Hydroxybenzoic Acid Derivatives in Mitigating Jellyfish Toxin-Induced Skin Damage: Insights into Protective and Reparative Mechanisms[J]. MARINE DRUGS,2024,22(5):22. |
| APA | Geng, Hao.,Li, Rongfeng.,Teng, Lichao.,Yu, Chunlin.,Wang, Wenjie.,...&Li, Pengcheng.(2024).Exploring the Efficacy of Hydroxybenzoic Acid Derivatives in Mitigating Jellyfish Toxin-Induced Skin Damage: Insights into Protective and Reparative Mechanisms.MARINE DRUGS,22(5),22. |
| MLA | Geng, Hao,et al."Exploring the Efficacy of Hydroxybenzoic Acid Derivatives in Mitigating Jellyfish Toxin-Induced Skin Damage: Insights into Protective and Reparative Mechanisms".MARINE DRUGS 22.5(2024):22. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。