Structural and functional characteristics of pectins from three cultivars of apple ( Malus pumila Mill.) pomaces
文献类型：期刊论文
| 作者 | Guo, Huan1,8; Li, Hang6,7; Ran, Wenyi1,8; Yu, Wenyue1,8; Xiao, Yue4,5; Gan, Renyou2,3; Gao, Hong1,8 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2024-06-01 |
| 卷号 | 269页码:14 |
| 关键词 | Apple pectin Immunostimulatory activity Structure -function relationship |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2024.132002 |
| 通讯作者 | Xiao, Yue(scu_xyue@163.com) ; Gao, Hong(gao523@hotmail.com) |
| 英文摘要 | This study aimed to investigate the chemical composition, structural properties, and biological properties of pectin polysaccharides (AP -FS, AP-QG, and AP -HG) isolated from different varieties of apple pomace. Based on the methylation and nuclear magnetic resonance analyses, the structure of AP -FS was determined to be composed of an alpha-1,4-linked homogalacturonan backbone that exhibited high levels of O-6 methylation. All pectins exhibit potent inhibitory activity against human colon cancer and human liver cancer cells, along with immunostimulatory effects. Among them, AP -FS exhibited the highest activity level. Finally, we further investigated the underlying mechanism behind the effect of AP -FS on RAW 264.7 cells using proteomics analysis. Our findings revealed that AP -FS triggers RAW 264.7 macrophage activation via NOD -like receptor (NLR), NF- kappa B, and mitogen-activated protein kinase (MAPK) signaling pathways. Therefore, our research contributes to a better understanding of the structure -function relationship among apple pectins, and AP -FS has the potential to be applied to dietary supplements targeting immunomodulation. |
| WOS关键词 | MACROPHAGE IMMUNOMODULATORY ACTIVITY ; POLYSACCHARIDE ; ESTERIFICATION ; DEGRADATION ; ANTIOXIDANT ; ACTIVATION ; FEATURES ; L. |
| 资助项目 | National Natural Science Foundation of China[32072321] ; Sichuan University and Luzhou City Strategic Cooperation Project[2019CDLZ-20] ; Liangshan Prefecture Technology Plan[21ZDYF0052] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001239780800001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/186023]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Xiao, Yue; Gao, Hong |
| 作者单位 | 1.Sichuan Univ, Coll Biomass Sci & Engn, Chengdu 610065, Peoples R China 2.ASTAR, Singapore Inst Food & Biotechnol Innovat SIFBI, 31 Biopolis Way, Singapore 138669, Singapore 3.Natl Univ Singapore, Dept Food Sci & Technol, 2 Sci Dr 2, Singapore 117542, Singapore 4.Sichuan Univ, West China Hosp 4, Chengdu 610041, Peoples R China 5.Sichuan Univ, West China Sch Publ Hlth, Chengdu 610041, Peoples R China 6.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 7.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 8.Sichuan Univ, Hlth Food Evaluat Res Ctr, Chengdu 610065, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Huan,Li, Hang,Ran, Wenyi,et al. Structural and functional characteristics of pectins from three cultivars of apple ( Malus pumila Mill.) pomaces[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,269:14. |
| APA | Guo, Huan.,Li, Hang.,Ran, Wenyi.,Yu, Wenyue.,Xiao, Yue.,...&Gao, Hong.(2024).Structural and functional characteristics of pectins from three cultivars of apple ( Malus pumila Mill.) pomaces.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,269,14. |
| MLA | Guo, Huan,et al."Structural and functional characteristics of pectins from three cultivars of apple ( Malus pumila Mill.) pomaces".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 269(2024):14. |
入库方式： OAI收割
来源：海洋研究所
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