The combined analysis of transcriptomics and metabolomics reveals the mechanisms by which dietary quercetin regulates growth and immunity in Penaeus vannamei
文献类型：期刊论文
| 作者 | Yang, Xuanyi1,2 ; Wang, Baojie2; Jiang, Keyong2; Xu, Kefeng3; Zhong, Chen3; Liu, Mei3; Wang, Lei1,2
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| 刊名 | FISH & SHELLFISH IMMUNOLOGY
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| 出版日期 | 2024-06-01 |
| 卷号 | 149页码:13 |
| 关键词 | Quercetin Growth Immunity Transcriptomics Metabolomics |
| ISSN号 | 1050-4648 |
| DOI | 10.1016/j.fsi.2024.109579 |
| 通讯作者 | Liu, Mei(mliu_msrisd@126.com) ; Wang, Lei(leiwang@qdio.ac.cn) |
| 英文摘要 | As a potent antioxidant, the flavonoid compound quercetin (QUE) has been widely used in the farming of aquatic animals. However, there are fewer reports of the beneficial effects, especially in improving immunity of Penaeus vannamei by QUE. The aim of this study was to investigate the effects of dietary QUE on growth, apoptosis, antioxidant and immunity of P . vannamei . It also explored the potential mechanisms of QUE in improving the growth and immunity of P . vannamei . P . vannamei were fed diets with QUE for 60 days. The results revealed that QUE (0.5 or 1.0 g/kg) ameliorated the growth, and the expressions of genes related to apoptosis, antioxidant, and immunity. The differentially expressed genes (DEGs) and differential metabolites (DMs) obtained through transcriptomics and metabolomics, respectively, enriched in pathways related to nutritional metabolism such as lipid metabolism, amino acid metabolism, and carbohydrate metabolism. After QUE addition, especially at 0.5 g/ kg, DEGs were enriched into the functions of response to stimulus and antioxidant activity, and the pathways of HIF-1 signaling pathway, C -type lectin receptor signaling pathway, Toll -like receptor signaling pathway, and FoxO signaling pathway. In conclusion, dietary QUE can ameliorate growth, apoptosis, antioxidant and immunity of P . vannamei , the appropriate addition amount was 0.5 g/kg rather than 1.0 g/kg. Regulations of QUE on nutrient metabolism and immune -related pathways, and bioactive metabolites, were important factors for improving the aforementioned abilities in P . vannamei . |
| WOS关键词 | INDUCED OXIDATIVE STRESS ; FLAVONOID QUERCETIN ; SIGNALING PATHWAY ; LARVAL ZEBRAFISH ; INNATE IMMUNITY ; APOPTOSIS ; SHRIMP ; ACTIVATION ; VIRUS ; INFLAMMATION |
| 资助项目 | Fund of the Key R & D Project of Shandong Province[2023TZXD047] ; Shandong Provincial Natural Science Foundation[ZR2023MC096] |
| WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001239302200001 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/186047]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Liu, Mei; Wang, Lei |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Key Lab Breeding Biotechnol & Sustainable Aquacult, Ctr Ocean Mega Sci,Inst Oceanol, Qingdao, Peoples R China 3.Marine Sci Res Inst Shandong Prov, Qingdao Aquat Organisms Qual Evaluat & Utilizat En, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xuanyi,Wang, Baojie,Jiang, Keyong,et al. The combined analysis of transcriptomics and metabolomics reveals the mechanisms by which dietary quercetin regulates growth and immunity in Penaeus vannamei[J]. FISH & SHELLFISH IMMUNOLOGY,2024,149:13. |
| APA | Yang, Xuanyi.,Wang, Baojie.,Jiang, Keyong.,Xu, Kefeng.,Zhong, Chen.,...&Wang, Lei.(2024).The combined analysis of transcriptomics and metabolomics reveals the mechanisms by which dietary quercetin regulates growth and immunity in Penaeus vannamei.FISH & SHELLFISH IMMUNOLOGY,149,13. |
| MLA | Yang, Xuanyi,et al."The combined analysis of transcriptomics and metabolomics reveals the mechanisms by which dietary quercetin regulates growth and immunity in Penaeus vannamei".FISH & SHELLFISH IMMUNOLOGY 149(2024):13. |
入库方式： OAI收割
来源：海洋研究所
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