Secondary metabolites with fungicide potentials from the deep-sea seamount-derived fungus Talaromyces scorteus AS-242
文献类型：期刊论文
| 作者 | Wang, Ying2,5 ; Li, Xiao-Ming2,5; Song, Ni4; Wang, Bin-Gui1,2,3,5; Li, Hong-Lei2,5; Meng, Ling-Hong1,2,5
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| 刊名 | BIOORGANIC CHEMISTRY
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| 出版日期 | 2024-06-01 |
| 卷号 | 147页码:10 |
| 关键词 | Cycloheptapeptides Terpenoids Talaromyces scorteus Antimicrobial activities Deep-sea seamount-derived fungus |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2024.107417 |
| 通讯作者 | Meng, Ling-Hong(menglh@ms.qdio.ac.cn) |
| 英文摘要 | Marine natural products play an important role in biopesticides. Seven new secondary metabolites with different structural classes, including two cycloheptapeptides, scortide A (1) and scortide B (2), two 19-nor-diterpenoids, talascortene H (3) and talascortene I (4), two diterpenoid acids, talascortene J (5) and talascortene K (6), and one triterpenoid, talascortene L (7) were isolated and identified from the sea-anemone-derived endozoic fungus Talaromyces scorteus AS-242. Their structures were comprehensively assigned by spectroscopic data analysis, single-crystal X-ray diffraction, tandem mass spectrometry, and electronic circular dichroism (ECD) calculations. The result of the antimicrobial assay demonstrated that compounds 1 - 6 have inhibitory activity against several human, aquatic, and plant pathogens with minimum inhibitory concentration (MIC) values ranging from 1 to 64 mu g/mL. Specially, compounds 2 and 4 showed significant activities against the pathogenic fungus Curvularia spicifera with the MIC value of 1 mu g/mL, providing an experimental basis of 2 and 4 with the potential as lead compounds to be developed into biopesticides. |
| WOS关键词 | TANDEM MASS-SPECTRA ; ABSOLUTE-CONFIGURATION ; CYCLIC HEPTAPEPTIDES ; PROLINE ; CARBON |
| 资助项目 | National Natural Science Foundation of China (NSFC)[42176115] ; National Natural Science Foundation of China (NSFC)[41976090] ; Senior User Project of RV KEXUE[KEX-UE2020GZ02] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001238098100002 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/186062]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Meng, Ling-Hong |
| 作者单位 | 1.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ying,Li, Xiao-Ming,Song, Ni,et al. Secondary metabolites with fungicide potentials from the deep-sea seamount-derived fungus Talaromyces scorteus AS-242[J]. BIOORGANIC CHEMISTRY,2024,147:10. |
| APA | Wang, Ying,Li, Xiao-Ming,Song, Ni,Wang, Bin-Gui,Li, Hong-Lei,&Meng, Ling-Hong.(2024).Secondary metabolites with fungicide potentials from the deep-sea seamount-derived fungus Talaromyces scorteus AS-242.BIOORGANIC CHEMISTRY,147,10. |
| MLA | Wang, Ying,et al."Secondary metabolites with fungicide potentials from the deep-sea seamount-derived fungus Talaromyces scorteus AS-242".BIOORGANIC CHEMISTRY 147(2024):10. |
入库方式： OAI收割
来源：海洋研究所
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