Dynamic Alternative Polyadenylation during Litopenaeus Vannamei Metamorphosis Development
文献类型：期刊论文
| 作者 | Yang, Xueqin4,5; Chen, Xiuli2,4; Liu, Chengzhang3 ; Wang, Zezhong5; Lei, Wei1; Li, Qiangyong2; Zhao, Yongzhen2,4; Wang, Xia4,5
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| 刊名 | GENES
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| 出版日期 | 2024-07-01 |
| 卷号 | 15期号:7页码:15 |
| 关键词 | alternative polyadenylation dynamic regulation Litopenaeus vannamei metamorphosis miRNA |
| DOI | 10.3390/genes15070837 |
| 通讯作者 | Zhao, Yongzhen(fisher1152002@126.com) ; Wang, Xia(xiawang@nwafu.edu.cn) |
| 英文摘要 | As an important mechanism in the post-transcriptional regulation of eukaryotic gene expression, alternative polyadenylation (APA) plays a key role in biological processes such as cell proliferation and differentiation. However, the role and dynamic pattern of APA during Litopenaeus vannamei metamorphosis are poorly understood. Here, RNA-seq data covering from the embryo to the maturation (16 time points) of L. vannamei were utilized. We identified 247 differentially expressed APA events between early and adult stages, and through fuzzy mean clustering analysis, we discovered five dynamic APA patterns. Among them, the gradual elongation of the 3 ' UTR is the major APA pattern that changes over time, and its genes are enriched in the pathways of protein and energy metabolism. Finally, we constructed mRNA-miRNA and PPI networks and detected several central miRNAs that may regulate L. vannamei development. Our results revealed the complex APA mechanisms in L. vannamei metamorphosis, shedding new light on post-transcriptional regulation of crustacean metamorphosis. |
| WOS关键词 | 3' UNTRANSLATED REGIONS ; MESSENGER-RNAS ; MECHANISMS ; EXPRESSION ; LANDSCAPE ; CLEAVAGE ; PROVIDES ; SUBUNIT ; ENERGY ; GENES |
| 资助项目 | Open fund of China (Guangxi)-ASEAN Key Laboratory of Comprehensive Exploitation and Utilization of Aquatic Germplasm Resources, Ministry of Agriculture and Rural Affairs[TG20231119] ; Modern Agroindustry Technology Research System of China[CARS-48-02] |
| WOS研究方向 | Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:001278781300001 |
| 出版者 | MDPI |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/186141]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Zhao, Yongzhen; Wang, Xia |
| 作者单位 | 1.Univ Manchester, Coll Pharm Nat & Hlth Sci, Dept Pharmaceut & Grad Life Sci, Ft Wayne, IN 46845 USA 2.Guangxi Acad Fishery Sci, Key Lab Aquaculture Genet & Breeding & Hlth Aquacu, Nanning 530021, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China 4.Guangxi Acad Fishery Sci, China Guangxi ASEAN Key Lab Comprehens Exploitat &, Minist Agr & Rural Affairs, Nanning 530021, Peoples R China 5.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xueqin,Chen, Xiuli,Liu, Chengzhang,et al. Dynamic Alternative Polyadenylation during Litopenaeus Vannamei Metamorphosis Development[J]. GENES,2024,15(7):15. |
| APA | Yang, Xueqin.,Chen, Xiuli.,Liu, Chengzhang.,Wang, Zezhong.,Lei, Wei.,...&Wang, Xia.(2024).Dynamic Alternative Polyadenylation during Litopenaeus Vannamei Metamorphosis Development.GENES,15(7),15. |
| MLA | Yang, Xueqin,et al."Dynamic Alternative Polyadenylation during Litopenaeus Vannamei Metamorphosis Development".GENES 15.7(2024):15. |
入库方式： OAI收割
来源：海洋研究所
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