The mechanism of low molecular weight fucoidan-incorporated nanofiber scaffolds inhibiting oral leukoplakia via SR-A/Wnt signal axis
文献类型：期刊论文
| 作者 | Xu, Ming1; Sun, Yu1; Cong, Beibei5; Zhang, Xiaopei4; Li, Zhenfeng3; Liu, Yingnan1; Geng, Lihua2; Qin, Qi1; Wu, Yingtao5; Gao, Meihua5 |
| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2024-07-22 |
| 卷号 | 15页码:17 |
| 关键词 | fucoidan electrospun nanofiber oral leukoplakia scavenger receptor A Wnt/beta-catenin |
| DOI | 10.3389/fphar.2024.1397761 |
| 通讯作者 | Wang, Yuanfei(zhizunbao19@163.com) ; Xu, Yingjie(xyjdywe@163.com) |
| 英文摘要 | Oral leukoplakia (OLK) is the most common oral precancerous lesion, and 3%-17% of OLK patients progress to oral squamous cell carcinoma. OLK is susceptible to recurrence and has no effective treatment. However, conventional drugs have significant side effects and limitations. Therefore, it is important to identify drugs that target OLK. In this study, scavenger receptor A (SR-A) was found to be abnormally highly expressed in the oral mucosal epithelial cells of OLK patients, whereas molecular biology studies revealed that low molecular weight fucoidan (LMWF) promoted apoptosis of dysplastic oral keratinocytes (DOK) and inhibited the growth and migration of DOK, and the inhibitory effect of LMWF on OLK was achieved by regulating the SR-A/Wnt signaling axis and related genes. Based on the above results and the special situation of the oral environment, we constructed LMWF/poly(caprolactone-co-lactide) nanofiber membranes with different structures for the in-situ treatment of OLK using electrospinning technology. The results showed that the nanofiber membranes with a shell-core structure had the best physicochemical properties, biocompatibility, and therapeutic effect, which optimized the LMWF drug delivery and ensured the effective concentration of the drug at the target point, thus achieving precise treatment of local lesions in the oral cavity. This has potential application value in inhibiting the development of OLK. |
| WOS关键词 | EXPRESSION ; POLYSACCHARIDES ; CLASSIFICATION ; ANTIOXIDANT ; ACTIVATION ; PATHWAY ; CANCER ; TCF4 |
| 资助项目 | National Natural Science Foundation of China10.13039/501100001809 |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001283563700001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/186177]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Yuanfei; Xu, Yingjie |
| 作者单位 | 1.Qingdao Univ, Qingdao Med Coll, Qingdao, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 3.Weifang Med Univ, Expt Ctr Med Res, Weifang, Peoples R China 4.Qingdao Univ, Inst Neuroregenerat & Neurorehabil, Qingdao Med Coll, Sch Basic Med,Dept Pathophysiol, Qingdao, Peoples R China 5.Qingdao Univ, Qingdao Stomatol Hosp, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Ming,Sun, Yu,Cong, Beibei,et al. The mechanism of low molecular weight fucoidan-incorporated nanofiber scaffolds inhibiting oral leukoplakia via SR-A/Wnt signal axis[J]. FRONTIERS IN PHARMACOLOGY,2024,15:17. |
| APA | Xu, Ming.,Sun, Yu.,Cong, Beibei.,Zhang, Xiaopei.,Li, Zhenfeng.,...&Xu, Yingjie.(2024).The mechanism of low molecular weight fucoidan-incorporated nanofiber scaffolds inhibiting oral leukoplakia via SR-A/Wnt signal axis.FRONTIERS IN PHARMACOLOGY,15,17. |
| MLA | Xu, Ming,et al."The mechanism of low molecular weight fucoidan-incorporated nanofiber scaffolds inhibiting oral leukoplakia via SR-A/Wnt signal axis".FRONTIERS IN PHARMACOLOGY 15(2024):17. |
入库方式： OAI收割
来源：海洋研究所
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