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Horizontal gene transfer plays a crucial role in the development of antibiotic resistance in an antibiotic-free shrimp farming system

文献类型：期刊论文

作者Chi, Wendan5; Zou, Yan; Qiu, Tianlong4; Shi, Wen3; Tang, Liuqing5; Xu, Mengxue5; Wu, Haiyi1,5; Luan, Xiao2
刊名JOURNAL OF HAZARDOUS MATERIALS
出版日期2024-09-05
卷号476页码:13
关键词Aquaculture system Antibiotic resistance Horizontal gene transfer Risk assessment and control Bacterial community
ISSN号0304-3894
DOI10.1016/j.jhazmat.2024.135150
通讯作者Wu, Haiyi(wuhaiyi1997@163.com) ; Luan, Xiao(luanxiao@iwhr.com)
英文摘要Antibiotic selective pressure in aquaculture systems often results in the antibiotic resistance genes (ARGs) proliferation. Nonetheless, a paucity of data exists concerning the mechanisms of ARGs development in aquaculture systems without the influences of antibiotics. This study utilized metagenomic approaches to elucidate the dynamics and transfer mechanisms of ARGs throughout the aquaculture of Pacific white shrimp. A marked change in the resistome was observed throughout the aquaculture without antibiotics. The total ARGs relative abundance increased from 0.05 to 0.33 by day 90 of cultivation, with even higher in mixed wastewater (0.44). Both bacterial communities and mobile genetic elements play pivotal roles in the development of ARGs. Metagenomeassembled genomes showed enrichment of environmentally intrinsic ARGs on chromosomes including mac B and mdt K. The plasmid-mediated horizontal transfer was recognized as a principal factor contributing to the rise of ARGs, particularly for tet G and flo R, and this led to an escalation of resistance risk, peaking at a risks core of 35.43 on day 90. This study demonstrates that horizontal gene transfer plays a crucial role in ARGs development without antibiotic pressure, which can provide a theoretical foundation for controlling ARGs proliferation in aquaculture systems.
WOS关键词WASTE-WATER TREATMENT ; HEALTH-RISK ; BACTERIA ; TETRACYCLINE ; FISH ; PERSISTENCE ; SULFONAMIDE
资助项目National Key Research and Development Program of China[2023YFC3207902] ; Key Research and Development Program of Shandong Province, China[2022CXGC010401] ; Key Research and Development Program of Shandong Province, China[2023CXGC010412] ; Earmarked fund for Modern Agricuture Shrimps and Crabs Industry Technology System of Shandong province[SDAIT-13-04]
WOS研究方向Engineering ; Environmental Sciences & Ecology
语种英语
WOS记录号WOS:001268387000001
出版者ELSEVIER
源URL[http://ir.qdio.ac.cn/handle/337002/186230]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Wu, Haiyi; Luan, Xiao
作者单位1.China Inst Water Resources & Hydropower Res, State Key Lab Simulat & Regulat Water Cycle River, Beijing 100048, Peoples R China
2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Aquat Chem, Beijing 100085, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
4.Qingdao Key Lab Coastal Ecol Restorat & Secur, Qingdao, Shandong, Peoples R China
5.Marine Sci Res Inst Shandong Prov, Qingdao 266104, Peoples R China
推荐引用方式
GB/T 7714		 Chi, Wendan,Zou, Yan,Qiu, Tianlong,et al. Horizontal gene transfer plays a crucial role in the development of antibiotic resistance in an antibiotic-free shrimp farming system[J]. JOURNAL OF HAZARDOUS MATERIALS,2024,476:13.
APA Chi, Wendan.,Zou, Yan.,Qiu, Tianlong.,Shi, Wen.,Tang, Liuqing.,...&Luan, Xiao.(2024).Horizontal gene transfer plays a crucial role in the development of antibiotic resistance in an antibiotic-free shrimp farming system.JOURNAL OF HAZARDOUS MATERIALS,476,13.
MLA Chi, Wendan,et al."Horizontal gene transfer plays a crucial role in the development of antibiotic resistance in an antibiotic-free shrimp farming system".JOURNAL OF HAZARDOUS MATERIALS 476(2024):13.

入库方式： OAI收割

来源：海洋研究所

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