Evolution of orphan and atypical histidine kinases and response regulators for microbial signaling diversity
文献类型：期刊论文
| 作者 | Xu, Gangming; Yang, Suiqun |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2024-08-01 |
| 卷号 | 275页码:14 |
| 关键词 | Two-component system Histidine kinase Response regulator |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2024.133635 |
| 通讯作者 | Xu, Gangming(aericxu@gmail.com) |
| 英文摘要 | Two-component signaling systems (TCS) are the predominant means of microbes for sensing and responding to environmental stimuli. Typically, TCS is comprised of a sensor histidine kinase (HK) and a cognate response regulator (RR), which might have coevolved together. They usually involve the phosphoryl transfer signaling mechanism. However, there are also some orphan and atypical HK and RR homologs, and their evolutionary origins are still not very clear. They are not associated with cognate pairs or lack the conserved residues for phosphoryl transfer, but they could receive or respond to signals from other regulators. The objective of this study is to reveal the evolutionary history of these orphan and atypical HK and RR homologs. Structural, domain, sequence, and phylogenetic analyses indicated that their evolution process might undergo gene duplication, divergence, and domain shuffling. Meanwhile, lateral gene transfer might also be involved for their gene distribution. Evolution of orphan and atypical HK and RR homologs have increased their signaling diversity, which could be helpful for microbial adaption in complex environments. |
| WOS关键词 | DI-GMP RECEPTOR ; PROTEIN-KINASE ; BIOFILM FORMATION ; RECEIVER DOMAIN ; VIBRIO-CHOLERAE ; SENSOR KINASES ; NMR STRUCTURE ; BINDING ; PHOSPHORYLATION ; INSIGHTS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001267171600001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/186347]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Xu, Gangming |
| 作者单位 | Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Gangming,Yang, Suiqun. Evolution of orphan and atypical histidine kinases and response regulators for microbial signaling diversity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,275:14. |
| APA | Xu, Gangming,&Yang, Suiqun.(2024).Evolution of orphan and atypical histidine kinases and response regulators for microbial signaling diversity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,275,14. |
| MLA | Xu, Gangming,et al."Evolution of orphan and atypical histidine kinases and response regulators for microbial signaling diversity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 275(2024):14. |
入库方式： OAI收割
来源：海洋研究所
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